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ホーム >  研究所 >  研究活動紹介 >  がん薬物療法研究部 >  発表論文リスト

発表論文リスト


主な論文(がんホスファトーム)

  • Kishimoto K, Kanazawa K, Nomura M, Tanaka T, Shigemoto-Kuroda T, Fukui K, Miura K, Kurosawa K, Kawai M, Kato H, Terasaki K, Sakamoto Y, Yamashita Y, Sato I, Tanuma N, Tamai K, Kitabayashi I, Matsuura K, Watanabe T, Yasuda J, Tsuji H, Shima H: Ppp6c deficiency accelerates K-ras(G12D)-induced tongue carcinogenesis.pp6c deficiency accelerates K-ras(G12D)-induced tongue carcinogenesis. Cancer Med. 2021 (Online ahead of print)

  • Kanazawa K, Kishimoto K, Nomura M, Kurosawa K, Kato H, Inoue Y, Miura K, Fukui K, Yamashita Y, Sato I, Tsuji H, Watanabe T, Tanaka T, Yasuda J, Tanuma N, Shima H: Ppp6c haploinsufficiency accelerates UV-induced BRAF(V600E)-initiated melanomagenesis. Cancer Sci. 112(6):2233-2244, 2021

  • Kurosawa K, Inoue Y, Kakugawa Y, Yamashita Y, Kanazawa K, Kishimoto K, Nomura M, Momoi Y, Sato I, Chiba N, Suzuki M, Ogoh H, Yamada H, Miura K, Watanabe T, Tanuma N, Tachi M, Shima H: Loss of protein phosphatase 6 in mouse keratinocytes enhances K-rasG12D -driven tumor promotion. Cancer Sci. 109(7):2178-2187, 2018

  • Yoshimaru T, Ono M, Bando Y, Yi-An Chen, Mizuguchi K, Shima H, Komatsu M, Imoto I, Izumi K, Honda J, Miyoshi Y, Sasa M and Katagiri T: A-kinase anchoring protein BIG3 coordinates oestrogen signaling in breast cancer cells. Nat. Commun. 8(1):1177, 2017

  • Ogoh H, Tanuma N, Matsui Y, Hayakawa N, Inagaki A, Sumiyoshi M, Momoi Y, Kishimoto A, Suzuki M, Sasaki N, Ohuchi T, Nomura M, Teruya Y, Yasuda K, Watanabe T, Shima H: The protein phosphatase 6 catalytic subunit (Ppp6c) is indispensable for proper post-implantation embryogenesis. Mech Dev. 139, 1-9, 2016

  • Hayashi K, Momoi Y, Tanuma N, Kishimoto A, Ogoh H, Kato H, Suzuki M, Sakamoto Y, Inoue Y, Nomura M, Kiyonari H, Sakayori M, Fukamachi K, Kakugawa Y, Yamashita Y, Ito S5, Sato I, Suzuki A, Nishio M, Suganuma M, Watanabe T, Shima H: Abrogation of protein phosphatase 6 promotes skin carcinogenesis induced by DMBA. Oncogene, 34(35): 4647-55, 2015

  • Kato H, Kurosawa K, Inoue Y, Tanuma N, Momoi Y, Hayashi K, Ogoh H, Nomura M, Sakayori M, Kakugawa Y, Yamashita Y, Miura K, Maemondo M, Katakura R, Ito S, Sato M, Sato I, Chiba N, Watanabe T, Shima H: Loss of protein phosphatase 6 in mouse keratinocytes increases susceptibility to ultraviolet-B-induced carcinogenesis. Cancer Lett. 365(2):223-8, 2015

主な論文(がん代謝)

  • Morita M, Kudo K, Shima H, Tanuma N.: Dietary intervention as a therapeutic for cancer. Cancer Sci, 112(2):498-504, 2021

  • Kikuchi N, Soga T, Nomura M, Sato T, Sakamoto Y, Tanaka R, Abe J, Morita M, Shima H, Okada Y, Tanuma N.: Comparison of the ischemic and non-ischemic lung cancer metabolome reveals hyper activity of the TCA cycle and autophagy. Biochem Biophys Res Commun, 530(1):285-291. 2020

  • Kudo K, Nomura M, Sakamoto Y, Ito S, Morita M, Kawai M, Yamashita Y, Ito K, Yamada H, Shima H, Yaegashi N, Tanuma N.: Divergent metabolic responses dictate vulnerability to NAMPT inhibition in ovarian cancer. FEBS Lett, 594(9):1379-1388.2020

  • Morita M, Sato T, Nomura M, Sakamoto Y, Inoue Y, Tanaka R, Ito S, Kurosawa K, Yamaguchi K, Sugiura Y, Takizaki H, Yamashita Y, Katakura R, Sato I, Kawai M, Okada Y, Watanabe H, Kondoh G, Matsumoto S, Kishimoto A, Obata M, Matsumoto M, Fukuhara T, Motohashi H, Suematsu M, Komatsu M, Nakayama KI, Watanabe T, Soga T, Shima H, Maemondo M and Tanuma N: PKM1 confers metabolic advantages and promotes cell-autonomous tumor cell growth. Cancer Cell, 33(3), 355-367. 2018

  • Sato T, Morita M, Nomura M, Tanuma N: Revisiting glucose metabolism in cancer: lessons from a PKM knock-in model. Mol Cell Oncol, 5(4):e1472054. 2018


その他、最近の論文

  • Ito S, Sato I, Mochizuki M, Yamaguchi K, Tamai K, Minato T, Tanuma N, Shima H and Yasuda J.:Robustness of a Cancer Profiling Test Using Formalin-fixed Paraffin Embedded Tumor Specimens. Anticancer Res.2021 March;41(3):1341-1348. doi:10.21873/anticanres.14891.

  • Tanuma SI, Katsuragi K, Oyama T, Yoshimori A, Shibasaki Y, Asawa Y, Yamazaki H, Makino K, Okazawa M, Ogino Y, Sakamoto Y, Nomura M, Sato A, Abe H, Nakamura H, Takahashi H, Tanuma N, Uchiumi F.:Structural Basis of Beneficial Design for Effective Nicotinamide Phosphoribosyltransferase Inhibitors. Molecules.25(16):E3633.2020

  • Abe J, Tanuma N, Nomura M, Ito S, Kasugai I, Sato I, Tamai K, Mochizuki M, Yamaguchi K, Shima H, Okada Y, Yasuda J.: Novel activating KRAS mutation candidates in lung adenocarcinoma. Biochem Biophys Res Commun. 2020 Feb 12;522(3):690-696.

  • Akaike T, Ida T, Wei F.-Y, Nishida M, Kumagai Y, Alam MM, Ihara H, Sawa T, Matsunaga T, Kasamatsu S, Nishimura A, Morita M, Tomizawa K, Nishimura A, Watanabe S, Inaba K, Shima H, Tanuma N, Jung M, Fujii S, Watanabe Y, Ohmuraya M, Nagy P, Feelisch M, Fukuto JM, Motohashi H: Cysteinyl-tRNA synthetase governs cysteine polysulfidation and mitochondrial bioenergetics. Nat Commun. 8:15427, 2017

  • Sato T, Morita M, Tanaka R, Inoue Y, Nomura M, Sakamoto Y, Miura K, Ito S, Sato I, Tanaka N, Abe J, Takahashi S, Kawai M, Sato M, Hippo Y, Shima H, Okada Y and Tanuma N: Ex vivo model of non-small cell lung cancer using mouse lung epithelial cells. Oncol Lett. 14(6): 6863-6868, 2017

  • Shiroki T, Yokoyama M, Tanuma N, Maejima R, Tamai K, Yamaguchi K, Oikawa T, Noguchi T, Miura K, Fujiya T, Shima HSato I, Kamiya N, Hatakeyama M, Iijima K, Shimosegawa T and Satoh K: Enhanced expression of the M2 isoform of pyruvate kinase is involved in gastric cancer development by regulating cancer-specific metabolism. Cancer Sci, 108(5):931-940, 2017

  • Miura K, Shima H, Takebe N, Julie R, Satoh K, Kakugawa Y, Satoh M, Kinouchi M, Yamamoto K, Hasegawa Y, Kawai M, Kanazawa K, Fujiya T, Unno M and Katakura R: Drug delivery of oral anti-cancer fluoropyrimidine agents. Expert Opin Drug Deliv. 11;1(12),2017

  • Matsuda S, Adachi J, Ihara M, Tanuma N, Shima H, Kakizuka A, Ikura M, Ikura T, Matsuda T: Nuclear pyruvate kinase M2 complex serves as a transcriptional coactivator of arylhydrocarbon receptor. Nucleic Acids Res. 44(2):636-47, 2016

  • Matsuda Y, Miura K, Yamane J, Shima H, Fujibuchi W, Ishida K, Fujishima F, Ohnuma S, Sasaki H, Nagao M, Tanaka N, Satoh K, Naitoh T, Unno M: SERPINI1 regulates the epithelial-mesenchymal transition in an orthotopic implantation model of colorectal cancer. Cancer Sci. 107(5):619-28, 2016

  • Yamamoto K, Takahashi K, Shiozaki K, Yamaguchi K, Moriya S, Hosono M, Shima H, Miyagi T: Potentiation of Epidermal Growth Factor-Mediated Oncogenic Transformation by Sialidase NEU3 Leading to Src Activation. PLoS One, 10(3): e0120578, 2015

  • Takahashi K, Hosono M, Sato I, Hata K, Wada T, Yamaguchi K, Nitta K, Shima H, Miyagi T: Sialidase NEU3 contributes neoplastic potential on colon cancer cells as a key modulator of gangliosides by regulating Wnt signaling. Int J Cancer. 37(7):1560-73, 2015

  • Sumiyoshi M, Masuda N, Tanuma N, Ogoh H, Imai E, Otsuka M, Hayakawa N, Ohno K, Matsui Y, Hara K, Gotoh R, Suzuki M, Rai S, Tanaka H, Matsumura I, Shima H, Watanabe T: Mice doubly-deficient in the Arf GAPs SMAP1 and SMAP2 exhibit embryonic lethality. FEBS Lett. 589(19 Pt B):2754-62. 2015

  • Konno M, Koseki J, Kawamoto K, Nishida N, Matsui H, Dewi DL, Ozaki M, Noguchi Y, Mimori K, Gotoh N, Tanuma N, Shima H, Doki Y, Mori M, Ishii H: Embryonic MicroRNA-369 Controls Metabolic Splicing Factors and Urges Cellular Reprograming. PLoS One. 10(7):e0132789, 2015

  • Hamabe A, Konno M, Tanuma N, Shima H, Tsunekuni K, Kawamoto K, Nishida N, Koseki J, Mimori K, Gotoh N, Yamamoto H, Doki Y, Mori M, Ishii H: Role of pyruvate kinase M2 in transcriptional regulation leading to epithelial-mesenchymal transition. Proc Natl Acad Sci U S A. 111(43):15526-31, 2014

  • Nakahata S, Ichikawa T, Maneesaay P, Saito Y, Nagai K, Tamura T, Manachai N, Yamakawa N, Hamasaki M, Kitabayashi I, Arai Y, Kanai Y, Taki T, Abe T, Kiyonari H, Shimoda K, Ohshima K, Horii A, Shima H, Taniwaki M, Yamaguchi R, Morishita K: Loss of NDRG2 expression activates PI3K-AKTsignalling via PTEN phosphorylation in ATLL and other cancers. Nat Commun. 5:3393, 2014

  • Notsuda H, Sakurada A, Endo C, Okada Y, Horii A, Shima H, Kondo T: p190A RhoGAP is involved in EGFR pathways and promotes proliferation,invasion and migration in lung adenocarcinoma cells. Int J Oncol. 43(5):1569-77, 2013

  • Nomura M, Shiiba K, Katagiri C, Kasugai I, Masuda K, Sato I, Sato M, Kakugawa Y, Nomura E, Hayashi K, Nakamura Y, Nagata T, Otsuka T, Katakura R, Yamashita Y, Sato M, Tanuma N, Shima H: Novel function of MKP-5/DUSP10, a phosphatase for stress-activated kinases, on ERK dependent gene expression, and up-regulation of its gene expression in colon carcinomas. Oncol Rep. 28(3):931-6, 2012

  • Takahashi K, Mitoma J, Hosono M, Shiozaki K, Sato C, Yamaguchi K, Kitajima K, Higashi H, Nitta K, Shima H, Miyagi T: Sialidase NEU4 Hydrolyzes Polysialic Acids of Neural Cell Adhesion Molecules and Negatively Regulates Neurite Formation by Hippocampal Neurons. J. Biol. Chem. 287(18):14816-26, 2012

  • Katagiri C, Masuda K, Nomura M, Tanoue K, Fujita S, Yamashita Y, Katakura R, Shiiba K, Nomura E, Sato M, Tanuma NShima H: DUSP13B/TMDP inhibits stress-activated MAPKs and suppresses AP-1-dependent gene expression. Mol Cell Biochem. 352(1-2): 155-162, 2011

  • Masuda K, Katagiri C, Nomura M, Sato M, Kakumoto K, Akagi T, Kikuchi K, Tanuma N, Shima H: MKP-7, a JNK phosphatase, blocks ERK-dependent gene activation by anchoring phosphorylated ERK in the cytoplasm. Biochem Biophys Res Commun. 5;393(2):201-6, 2010

  • Yamashita Y, Kasugai I, Sato M, Tanuma N, Sato I, Nomura M, Yamashita K, Sonoda Y, Kumabe T, Tominaga T, Katakura R, Shima H: CDC25A mRNA levels significantly correlate with Ki-67 expression in human glioma samples. J Neurooncol. 100(1):43-9, 2010

  • Van Dessel N, Beke L, Görnemann J, Minnebo N, Beullens M, Tanuma N, Shima H, Van Eynde A, Bollen M.: The phosphatase interactor NIPP1 regulates the occupancy of the histone methyltransferase EZH2 at Polycomb targets. Nucleic Acids Res. 38(21):7500-7512, 2010

  • Tanuma N, Nomura M, Ikeda M, Kasugai I, Tsubaki Y, Takagaki K,Kawamura T, Yamashita Y, Sato I, Sato M, Katakura R, Kikuchi K, Shima H: Protein phosphatase Dusp26 associates with KIF3 motor and promotes N-cadherin-mediated cell-cell adhesion. Oncogene, 13: 752-761, 2009

  • Tanuma N, Kim S-E, Beullens M, Tsubaki Y, Mitsuhashi S, Nomura M, Kawamura T, Isono K, Koseki H, Sato M, Bollen M, Kikuchi K, Shima H: Nuclear inhibitor of protein phosphatase-1 (NIPP1) directs protein phosphatase-1 (PP1) to dephosphorylate the U2 snRNP component, spliceosome-associated protein 155 (Sap155). J Biol Chem. 283: 35805-35814, 2008

  • Mitsuhashi S, Shima H, Li Y, Tanuma N, Okamoto T, Kikuchi K, Ubukata M. Tautomycetin suppresses the TNFa/NFkB pathway via inhibition of IKK activation. Int J Oncol. 33: 1027-1035, 2008

  • Kumeta H, Ogura K, Adachi S, Fujioka Y, Tanuma N, Kikuchi K, Inagaki G. The NMR structure of the NIPP1 FHA domain. J Biomol. NMR. 40: 219-214, 2008

  • Mitsuhashi S, Saito A, Nakajima N, Shima H, Ubukata M. Pyrogallol structure in polyphenol is involved in apoptosis-induction on HEK293T and K562 cells. Molecules. 13: 2998-3006, 2008