グローバルナビゲーションへ

本文へ

ローカルナビゲーションへ

フッターへ



ホーム >  研究所 >  研究活動紹介 >  がん先進治療開発研究部 >  発表論文リスト

発表論文リスト


2016年

  • Kobayashi EH, Suzuki T, Funayama R, Nagashima T, Hayashi M, Sekine H, Tanaka N, Moriguchi T, Motohashi H, Nakayama K, Yamamoto M. Nrf2 suppresses macrophage inflammatory response by blocking proinflammatory cytokine transcription. Nature Commun. 7:11624. doi: 10.1038/ncomms11624. (2016)

  • Mochizuki, M. Tamai, K.Imai, T.Sugawara, S.Ogama, N.Nakamura, M.Matsuura, K.Yamaguchi, K.Satoh, K.Sato, I.Motohashi, H.Sugamura, K.Tanaka, N. CD271 regulates the proliferation and motility of hypopharyngeal cancer cells. Scientific Reports 6, Article number: 30707. DOI: 10.1038/srep30707 (2016)

  • Oshima R, Hasegawa, T. Tamai, K. Sugeno, N, Yoshida, S., Kobayashi, J., Kikuchi, A, Baba, T, Futatsugi, A Sato, I, Satoh, K, Takeda, A., Aoki M, & Tanaka, N. ESCRT-0 dysfunction compromises autophagic degradation of protein aggregates and facilitates ER stress-mediated neurodegeneration via apoptotic and necroptotic pathways. Scientific Reports 6, Article number: 24997 doi:10.1038/srep24997 (2016)

  • Yamaguchi K, Takanashi T, Nasu K, Tamai K, Mochizuki M, Satoh I, Ine S, Sasaki O, Satoh K, Tanaka N, Harigae H, Sugamura K. Xenotransplantation elicits salient tumorigenicity of adult T-cell leukemia-derived cells via aberrant AKT activation. Cancer Science. 107(5):638-43.. doi: 10.1111/cas.12921. (2016)

  • Mizuguchi M, Sasaki Y, Hara T, Higuchi M, Tanaka Y, Funato N, Tanaka N, Fujii M, Nakamura M. Induction of Cell Death in Growing Human T-Cells and Cell Survival in Resting Cells in Response to the Human T-Cell Leukemia Virus Type 1 Tax. PLoS One, 11(2):e0148217. (2016)

  • Watanabe K, Fukuhara T, Tsukita Y, Morita M, Suzuki A, Tanaka N, Terasaki H, Nukiwa T, Maemondo M. EGFR Mutation Analysis of Circulating Tumor DNA Using an Improved PNA-LNA PCR Clamp Method. Can Respir J.:5297329. doi: 10.1155/2016/5297329.(2016)

  • Maejima R, Tamai K, Shiroki T, Yokoyama M, Shibuya R, Nakamura M, Yamaguchi K, Abue M, Oikawa T, Noguchi T, Miura K, Fujiya T, Sato I, Iijima K, Shimosegawa T, Tanaka N, Satoh K. Enhanced expression of semaphorin 3E is involved in the gastric cancer development. Int J Oncol. 49(3):887-94. doi: 10.3892/ijo.2016.3593.(2016)

2014年

  • Tamai K, Nakamura M, Mizuma M, Mochizuki M, Yokoyama M, Endo H, Yamaguchi K, Nakagawa T, Shiina M, Unno M, Muramoto K, Sato I, Satoh K, Sugamura K, Tanaka N.Suppressive expression of CD274 increases tumorigenesis and cancer stem cell phenotypes in cholangiocarcinoma.Cancer Sci. 2014 Jun;105(6):667-74. doi: 10.1111/cas.124

  • Kojima, K., Amano, Y., Yoshino, K., Tanaka, N., Sugamura, K., Takeshita, T. ESCRT-0 protein hepatocyte growth factor-regulated tyrosine kinase substrate (Hrs) is targeted to endosomes independently of signal-transducing adaptor molecule (STAM) and the complex formation with STAM promotes its endosomal dissociation J Biol Chem 289, 33296-33310 (2014)

  • Sugeno, N., Hasegawa, T., Tanaka, N., Fukuda, M., Wakabayashi, K., Oshima, R., Konno, M., Miura, E., Kikuchi, A., Baba, T., Anan, T., Nakao, M., Geisler, S., Aoki, M., Takeda, A. Lys-63-linked ubiquitination by E3 ubiquitin ligase Nedd4-1 facilitates endosomal sequestration of internalized alpha-synuclein. J Biol Chem 289, 18137-18151 (2014)

  • Watanuki, Z.Kosai, H., Osanai, N., Ogama, N., Mochizuki, M., Tamai, K., Yamaguchi, K., Satoh, K., Fukuhara, T., Maemondo, M., Ichinose, M., Nukiwa, T., Tanaka, N. Synergistic cytotoxicity of afatinib and cetuximab against EGFR T790M involves Rab11-dependent EGFR recycling. Biochem Biophy Res Commun. 455, 269-276 (2014)

  • Abue, M., Yokoyama, M., Shibuya, R., Tamai, K., Yamaguchi, K., Sato, I., Tanaka, N., Hamada, S., Shimosegawa, T., Sugamura, K., Satoh, K. Circulating miR-483-3p and miR-21 is highly expressed in plasma of pancreatic cancer. Int J Oncol 46, 539-547 (2014)

  • Abue, M., Yokoyama, M., Shibuya, R., Tamai, K., Yamaguchi, K., Sato, I., Tanaka, N., Hamada, S., Shimosegawa, T., Sugamura, K., Satoh, K. Circulating miR-483-3p and miR-21 is highly expressed in plasma of pancreatic cancer. Int J Oncol ov 10. doi: 10.3892/ijo.2014.2743. (2014)

  • Nagata T, Murata K, Murata R, Sun SL, Saito Y, Yamaga S, Tanaka N, Tamai K, Moriya K, Kasai N, Sugamura K, Ishii N. Hepatocyte growth factor regulated tyrosine kinase substrate in the peripheral development and function of B-cells. Biochem Biophys Res Commun. 443(2):351-6 (2014)

2013年

  • Endo H, Shiroki T, Nakagawa T, Yokoyama M, Tamai K, Yamanami H, Fujiya T, Sato I, Yamaguchi K, Tanaka N, Iijima K, Shimosegawa T, Sugamura K, Satoh K. Enhanced expression of long non-coding RNA HOTAIR is associated with the development of gastric cancer. PLoS One. 2013 Oct 10;8(10):e77070 (2013).

  • Nakagawa T, Endo H, Yokoyama M, Abe J, Tamai K, Tanaka N, Sato I, Takahashi S, Kondo T, Satoh K. Large noncoding RNA HOTAIR enhances aggressive biological behavior and is associated with short disease-free survival in human non-small cell lung cancer. Biochem Biophy Res Commun. 436, 319-324 (2013)

  • Imai T, Tamai K, Oizumi S, Oyama K, Yamaguchi K, Sato I, Satoh K, Matsuura K, Saijo S, Sugamura K, Tanaka N.CD271 defines a stem cell-like population in hypopharyngeal cancer.PLoS One. 2013 Apr 23;8(4):e62002.

2012年

  • Kondo Y, Ueno Y, Ninomiya M, Tamai K, Tanaka Y, Inoue J, Kakazu E, Kobayashi K, Kimura O, Miura M, Yamamoto T, Kobayashi T, Igarashi T, Shimosegawa T. Sequential immunological analysis of HBV/HCV co-infected patients during Peg-IFN/RBV therapy. J Gastroenterol. 2012 Dec;47(12):1323-35.

  • Inoue D, Suzuki T, Mitsuishi Y, Miki Y, Suzuki S, Sugawara S, Watanabe M, Sakurada A, Endo C, Uruno A, Sasano H, Nakagawa T, Satoh K, Tanaka N, Kubo H, Motohashi H, Yamamoto M. Accumulation of p62/SQSTM1 is associated with poor prognosis in patients with lung adenocarcinoma. Cancer Sci. 103:760-6. (2012)

  • Tamai K, Shiina M, Tanaka N, Nakano T, Yamamoto A, Kondo Y, Kakazu E, Inoue J, Fukushima K, Sano K, Ueno Y, Shimosegawa T, Sugamura K. Regulation of hepatitis C virus secretion by the Hrs-dependent exosomal pathway. Virology. 2012 Jan 20;422(2):377-85.

2011年

  • Kakazu E, Ueno Y, Kondo Y, Inoue J, Ninomiya M, Kimura O, Wakui Y, Fukushima K, Tamai K, Shimosegawa T.
    Plasma L-cystine/L-glutamate imbalance increases tumor necrosis factor-alpha from CD14+ circulating monocytes in patients with advanced cirrhosis.
    PLoS One. 2011;6(8):e23402.

  • Kondo Y, Ueno Y, Kakazu E, Kobayashi K, Shiina M, Tamai K, Machida K, Inoue J, Wakui Y, Fukushima K, Obara N, Kimura O, Shimosegawa T.
    Lymphotropic HCV strain can infect human primary naive CD4+ cells and affect their proliferation and IFN-γ secretion activity.
    J Gastroenterol. 2011 Feb;46(2):232-41. Epub 2010 Aug 17.

  • Suzuki S, Tamai K, Watanabe M, Kyuuma M, Ono M, Sugamura K, Tanaka N.
    AMSH is required to degrade ubiquitinated proteins in the central nervous system.Biochem Biophys Res Commun. 2011 May 20;408(4):582-8.

  • Amano Y, Yamashita Y, Kojima K, Yoshino K, Tanaka N, Sugamura K, Takeshita T. Hrs Recognizes a Hydrophobic Amino Acid Cluster in Cytokine Receptors during Ubiquitin-independent Endosomal Sorting. J Biol Chem. 2011 ; 286: 15458-72.

  • Inoue J, Ueno Y, Wakui Y, Niitsuma H, Fukushima K, Yamagiwa Y, Shiina M, Kondo Y, Kakazu E, Tamai K, Obara N, Iwasaki T, Shimosegawa T. Four-year study of lamivudine and adefovir combination therapy in lamivudine-resistant hepatitis B patients: influence of hepatitis B virus genotype and resistance mutation pattern. Journal of Viral Hepatitis, 2011, 18, 206-215

2010年

  • Tamai K, Tanaka N, Nakano T, Kakazu E, Kondo Y, Inoue J, Shiina M, Fukushima K, Hoshino T, Sano K, Ueno Y, Shimosegawa T, Sugamura K. Exosome secretion of dendritic cells is regulated by Hrs, an ESCRT-0 protein. Biochem Biophys Res Commun. 27; 399(3): 384-90, 2010.

  • Kondo Y, Ueno Y, Kobayashi K, Kakazu E, Shiina M, Inoue J, Tamai K, Wakui Y, Tanaka Y, Ninomiya M, Obara N, Fukushima K, Ishii M, Kobayashi T, Niitsuma H, Kon S, Shimosegawa T. Hepatitis B virus replication could enhance regulatory T cell activity by producing soluble heat shock protein 60 from hepatocytes. J Infect Dis. 2010 Jul 15; 202(2):202-13.

  • Obara N, Fukushima K, Ueno Y, Wakui Y, Kimura O, Tamai K, Kakazu E, Inoue J, Kondo Y, Ogawa N, Sato K, Tsuduki T, Ishida K, Shimosegawa T. Possible involvement and the mechanisms of excess trans-fatty acid consumption in severe NAFLD in mice. J Hepatol. 2010 Aug;53(2):326-34.

  • Nara H, Onoda T, Rahman M, Araki A, Juliana FM, Tanaka N, Asano H. Regulation of interleukin-21 receptor expression and its signal transduction by WSB-2. Biochem Biophy Res Commun. 171-7(2010)

2009年

  • Kakazu E, Ueno Y, Kondo Y, Fukushima K, Shiina M, Inoue J, Tamai K, Ninomiya M, Shimosegawa T. Branched chain amino acids enhance the maturation and function of myeloid dendritic cells ex vivo in patients with advanced cirrhosis. Hepatology. 2009 Dec; 50(6):1936-45.

  • Inoue J, Ueno Y, Nagasaki F, Akahane T, Fukushima K, Kogure T, Kondo Y, Kakazu E, Tamai K, Kido O, Nakagome Y, Ninomiya M, Obara N, Wakui Y, Takahashi M, Okamoto H, Shimosegawa T. Sporadic acute hepatitis E occurred constantly during the last decade in northeast Japan. J Gastroenterol. 2009; 44(4):329-37

  • Yamada K, Tsukahara T, Yoshino K, Kojima K, Agawa H, Yamashita Y, Amano Y, Hatta M, Matsuzaki Y, Kurotori N, Wakui K, Fukushima Y, Osada R, Shiozawa T, Sakashita K, Koike K, Kumaki S, Tanaka N, Takeshita T. Identification of a high incidence region for retroviral vector integration near exon 1 of the LMO2 locus. Retrovirology. 6, 79. (2009)

2008年

  • Tamai, K, Toyoshima, M, *Tanaka, N, Yamamoto, N, Owada, Y, Kiyonari, H, Murata K., Ueno Y., Ono M., Shimosegawa T., Yaegashi,N, Watanabe M, and Sugamura, K. Loss of Hrs in the Central Nervous System Causes Accumulation of Ubiquitinated Proteins and Neurodegeneration. Am.J.Pathol. 173,1806-17, (2008)

  • Tanaka Y, *Tanaka, N, Saeki Y, Tanaka K, Murakami M, Hirano T, Ishii N, Sugamura K.
    c-Cbl-dependent Monoubiquitination and Lysosomal Degradation of gp130. Mol. Cell. Biol. 28: 4805-4818, (2008)

  • *Tanaka, N、 Kyuuma M, Sugamura K. Endosomal sorting complex required for transport proteins in cancer pathogenesis, vesicular transport, and non-endosomal functions.Cancer Sci. 99: 1293-303, (2008)

  • Duechting A, Tschope C, Kaiser H, Lamkemeyer T, Tanaka N, Aberle S, Lang F, Torresi J, Kandolf R, Bock CT. Human parvovirus B19 NS1 protein modulates inflammatory signaling by activation of STAT3/PIAS3 in human endothelial cells. J Virol. 82:7942-7952. (2008)

  • Yamashita Y, Kojima K, Tsukahara T, Agawa H, Yamada K, Amano Y, Kurotori N, Tanaka N, Sugamura K, Takeshita T. Ubiquitin-independent binding of Hrs mediates endosomal sorting of the interleukin-2 receptor β-chain. J. Cell. Sci. 121: 1727-38, (2008)

2007年

  • Toyoshima M, *Tanaka N, Aoki J, Tanaka Y, Murata K, Kyuuma M, Kobayashi H, Ishii N, Yaegashi N, Sugamura K. Inhibition of tumor growth and metastasis by depletion of vesicular sorting protein Hrs: its regulatory role on E-cadherin and beta-catenin. Cancer Res. 67:5162-71. (2007)

  • Onoda T, Rahman M, Nara H, Araki A, Makabe K, Tsumoto K, Kumagai I, Kudo T, Ishii N, Tanaka N, Sugamura K, Hayasaka K, Asao H. Human CD4+ central and effector memory T cells produce IL-21: effect on cytokine-driven proliferation of CD4+ T cell subsets. Int Immunol. 10:1191-9, (2007)

  • Tamai,K, Tanaka, N., Nara, A, Yamamoto,A Nakagawa, I., Yoshimori, T. Ueno, U, Shimosegawa, T, and Sugamura K. Role of Hrs in Maturation of Autophagosomes in Mammalian Cell. Biochem Biophys Res Commun. 360, 721-7, (2007)

  • Inoue Y, Tanaka N, Tanaka Y, Inoue S, Morita K, Min Z, Hattori T, Sugamura K. Clathrin-dependent Entry of SARS Coronavirus into Target Cells Expressing Cytoplasmic Tail-deleted ACE2.J Virol. 81, 8722-9, (2007)

  • Kyuuma M, Kikuchi K, Kojima K, Sugawara Y, Sato M, Mano N, Goto J, Takeshita T, Yamamoto A, Sugamura K, Tanaka N. AMSH, an ESCRT-III associated enzyme, deubiquitinates cargo on MVB/late endosomes. Cell Struct Funct. 31:159-72, (2007)

2006年

  • Nakamura M, Tanaka N, Kitamura N and Komada M. Clathrin anchors deubiquitinating enzymes, AMSH and AMSH-like protein, on early endosomes. Gene Cells
    11, 593-606,(2006)

  • Nakashima A, Tanaka N, Tamai K, Kyuuma M, Ishikawa Y, Sato H, Yoshimori T, Saito S, Sugamura K. Survival of parvovirus B19-infected cells by cellular autophagy. Virology. 5, 349, 254-63, (2006)

  • Ishikawa Y, Tanaka N, Murakami K, Uchiyama T, Kumaki S, Tsuchiya S, Kugoh H, Oshimura M, Calos MP, Sugamura K. Phage phiC31 integrase-mediated genomic integration of the common cytokine receptor gamma chain in human T-cell lines. J Gene Med.;8:646-653, (2006)

  • Uchiyama T, Kumaki S, Ishikawa Y, Onodera M, Sato M, Du W, Sasahara Y, Tanaka N, Sugamura K, Tsuchiya S. Application of HSVtk suicide gene to X-SCID gene therapy: ganciclovir treatment offsets gene corrected X-SCID B cells. Biochem Biophys Res Commun.;341(2):391-8, (2006)

2005年

  • Shim JH, Xiao C, Paschal AE, Bailey ST, Rao P, Hayden MS, Lee KY, Bussey C, Steckel M, Tanaka N, Yamada G, Akira S, Matsumoto K, Ghosh S. TAK1, but not TAB1 or TAB2, plays an essential role in multiple signaling pathways in vivo. Genes Dev. ;19(22):2668-81.(2005)

  • Niinuma A, Higuchi M, Takahashi M, Oie M, Tanaka Y, Gejyo F, Tanaka N, Sugamura K, Xie L, Green PL, Fujii M. Aberrant activation of the interleukin-2 autocrine loop through the nuclear factor of activated T cells by nonleukemogenic human T-cell leukemia virus type 2 but not by leukemogenic type 1 virus. J Virol. 79:11925-34, (2005)

  • Kobayashi H, Tanaka N, Asao H, Miura S, Kyuuma M, Semura K, Ishii N, Sugamura K. Hrs, a mammalian master molecule in vesicular transport and protein sorting, suppresses the degradation of ESCRT proteins signal transducing adaptor molecule 1 and 2. J Biol Chem.; 280:10468-77,(2005)