H. Fujimori*, M. Shima-Nakamura, SI. Kanno, R. Shibuya-Takahashi, M. Mochizuki, M. Mizuma, M. Unno, Y. Wakui , M. Abue, W. Iwai, D. Fukushi, K. Satoh, K. Yamaguchi, N. Shindo, J. Yasuda, K. Tamai, FAXC interacts with ANXA2 and SRC in mitochondria and promotes tumorigenesis in cholangiocarcinoma, Cancer Sci. (2024). doi: 10.1111/cas.16140. Epub ahead of print. PMID: 38480477.
2023年
A. Yasumoto, H. Fujimori, M. Mochizuki, R. Shibuya-Takahashi, M. Nakamura-Shima, N. Shindo, K. Yamaguchi, D. Fukushi, Y. Wakui, T. Sugai, W. Iwai, M. Abue, I. Sato, K. Satoh, Y. Katayose, J. Yasuda, C. Shibata, K. Tamai*, BEX2 is poor prognostic factor and required for cancer stemness in gastric cancer, Biochemical and Biophysical Research Communications. (2023). https://doi.org/10.1016/j.bbrc.2023.03.025.
S. Miyabe, S. Ito, I. Sato, J. Abe, K. Tamai, M. Mochizuki, H. Fujimori, K. Yamaguchi, N. Shindo, H. Shima, T. Yamazaki, M. Abue, Y. Okada, J. Yasuda, Clinical and genomic features of non-small cell lung cancer occurring in families, Thorac Cancer. (2023). https://doi.org/10.1111/1759-7714.14825.
2022年
A. Nakazato, M. Mochizuki, R. Shibuya-Takahashi, H. Fujimori, K. Fujii, S. Saijoh, S. Morita, T. Yamazaki, T. Imai, I. Sato, K. Satoh, K. Yamaguchi, K. Sugamura, J. Yasuda, K. Matsuura, H. Shojaku, Y. Asada, K. Tamai*, RELA is required for CD271 expression and stem-like characteristics in hypopharyngeal cancer, Sci Rep. 12 (2022) 17751. https://doi.org/10.1038/s41598-022-22736-6.
K. Fujii, S. Morita, M. Mochizuki, R. Shibuya-Takahashi, H. Fujimori, K. Yamaguchi, J. Abe, T. Yamazaki, T. Imai, K. Sugamura, J. Yasuda, K. Satoh, I. Sato, R. Saito-Koyama, F. Fujishima, H. Sasano, Y. Kato, K. Matsuura, Y. Asada, K. Tamai*, Establishment of a monoclonal antibody against glycosylated CD271 specific for cancer cells in immunohistochemistry, Cancer Sci. (2022). https://doi.org/10.1111/cas.15340.
K. Fukui, M. Nomura, K. Kishimoto, N. Tanuma, K. Kurosawa, K. Kanazawa, H. Kato, T. Sato, S. Miura, K. Miura, I. Sato, H. Tsuji, Y. Yamashita, K. Tamai, T. Watanabe, J. Yasuda, T. Tanaka, K. Satoh, T. Furukawa, K. Jingu, H. Shima, PP6 deficiency in mice with KRAS mutation and Trp53 loss promotes early death by PDAC with cachexia-like features, Cancer Sci. (2022). https://doi.org/10.1111/cas.15315.
S. Ito, A. Hashimoto, K. Yamaguchi, S. Kawamura, S. Myoen, M. Ogawa, I. Sato, T. Minato, S. Miyabe, A. Nakazato, K. Fujii, M. Mochizuki, H. Fujimori, K. Tamai, T. Niihori, Y. Aoki, A. Sugawara, H. Sasano, H. Shima, J. Yasuda, A novel 8.57-kb deletion of the upstream region of PRKAR1A in a family with Carney complex, Mol Genet Genomic Med. (2022) e1884. https://doi.org/10.1002/mgg3.1884.
K. Tamai*, H. Fujimori, M. Mochizuki, K. Satoh, Cancer Stem Cells in Intrahepatic Cholangiocarcinoma; Their Molecular Basis, and Therapeutic Implications, Frontiers in Physiology. 12 (2022). https://www.frontiersin.org/article/10.3389/fphys.2021.824261 /s41598-021-03708-8.（Review）
2021年
S. Kawai, K. Nakano, K. Tamai, E. Fujii, M. Yamada, H. Komoda, H. Sakumoto, O. Natori, M. Suzuki, Generation of a lung squamous cell carcinoma three-dimensional culture model with keratinizing structures, Sci Rep. 11 (2021) 24305. https://doi.org/10.1038/s41598-021-03708-8.
D. Fukushi, R. Shibuya-Takahashi, M. Mochizuki, H. Fujimori, T. Kogure, T. Sugai, W. Iwai, Y. Wakui, M. Abue, K. Murakami, Y. Nakamura, J. Yasuda, K. Yamaguchi, K. Sugamura, C. Shibata, Y. Katayose, K. Satoh,K. Tamai*, BEX2 is required for maintaining dormant cancer stem cell in hepatocellular carcinoma, Cancer Sci. (2021). https://doi.org/10.1111/cas.15115.
T. Minato, S. Ito, B. Li, H. Fujimori, M. Mochizuki, K. Yamaguchi, K. Tamai, M. Shimada, H. Tokunaga, S. Shigeta, I. Sato, H. Shima, H. Yamada, N. Yaegashi, J. Yasuda, Liquid biopsy with droplet digital PCR targeted to specific mutations in plasma cell-free tumor DNA can detect ovarian cancer recurrence earlier than CA125, Gynecologic Oncology Reports. (2021) 100847. https://doi.org/10.1016/j.gore.2021.100847.
K. Kishimoto, K. Kanazawa, M. Nomura, T. Tanaka, T. Shigemoto-Kuroda, K. Fukui, K. Miura, K. Kurosawa, M. Kawai, H. Kato, K. Terasaki, Y. Sakamoto, Y. Yamashita, I. Sato, N. Tanuma,K. Tamai, I. Kitabayashi, K. Matsuura, T. Watanabe, J. Yasuda, H. Tsuji, H. Shima, Ppp6c deficiency accelerates K-rasG12D -induced tongue carcinogenesis, Cancer Med. 10 (2021) 4451–4464. https://doi.org/10.1002/cam4.3962.
S. Saijoh, M. Nakamura-Shima, R. Shibuya-Takahashi, R. Ito, A. Sugawara, T. Yamazaki, T. Imai, Y. Asada, K. Matsuura, W. Iwai, Y. Wakui, M. Abue, S. Kawamura, Y. Katayose, H. Fujimori, M. Mochizuki, J. Yasuda, K. Yamaguchi, K. Sugamura, K. Satoh, Y. Katori, K. Tamai*, Discovery of a chemical compound that suppresses expression of BEX2, a dormant cancer stem cell-related protein, Biochem Biophys Res Commun. 537 (2021) 132–139. https://doi.org/10.1016/j.bbrc.2020.11.022.
H. Mizuta, K. Okada, M. Araki, J. Adachi, A. Takemoto, J. Kutkowska, K. Maruyama, N. Yanagitani, T. Oh-Hara, K. Watanabe, K. Tamai, L. Friboulet, K. Katayama, B. Ma, Y. Sasakura, Y. Sagae, M. Kukimoto-Niino, M. Shirouzu, S. Takagi, S. Simizu, M. Nishio, Y. Okuno, N. Fujita, R. Katayama, Gilteritinib overcomes lorlatinib resistance in ALK-rearranged cancer, Nat Commun. 12 (2021) 1261. https://doi.org/10.1038/s41467-021-21396-w.
S. Ito, I. Sato, M. Mochizuki, K. Yamaguchi, K. Tamai, T. Minato, N. Tanuma, H. Shima, J. Yasuda, Robustness of a Cancer Profiling Test Using Formalin-fixed Paraffin Embedded Tumor Specimens, Anticancer Res. 41 (2021) 1341–1348. https://doi.org/10.21873/anticanres.14891.
2020年
K. Tamai*, M. Nakamura-Shima, R. Shibuya-Takahashi, S.-I. Kanno, A. Yasui, M. Mochizuki, W. Iwai, Y. Wakui, M. Abue, K. Yamamoto, K. Miura, M. Mizuma, M. Unno, S. Kawamura, I. Sato, J. Yasuda, K. Yamaguchi, K. Sugamura, K. Satoh, BEX2 suppresses mitochondrial activity and is required for dormant cancer stem cell maintenance in intrahepatic cholangiocarcinoma, Scientific Reports. 10 (2020) 21592. https://doi.org/10.1038/s41598-020-78539-0.
Y. Hatsuzawa, K. Yamaguchi, T. Takanashi, I. Sato, K. Tamai, M. Mochizuki, W. Iwai, Y. Wakui, M. Abue, K. Yamamoto, J. Yasuda, M. Mizuma, M. Unno, K. Sugamura, CD109 promotes the tumorigenic ability and metastatic motility of pancreatic ductal adenocarcinoma cells, Pancreatology. 20 (2020) 493–500. https://doi.org/10.1016/j.pan.2020.01.013.
S. Morita, M. Mochizuki, R. Shibuya-Takahashi, M. Nakamura-Shima, T. Yamazaki, T. Imai, Y. Asada, K. Matsuura, S. Kawamura, K. Yamaguchi, J. Yasuda, K. Sugamura, Y. Katori, K. Satoh, K. Tamai*. Establishment of a monoclonal antibody that recognizes cysteine-rich domain 1 of human CD271. Monoclonal Antibodies in Immunodiagnosis and Immunotherapy, 39 (2020) 6-11
2019年
S. Morita, M. Mochizuki, K. Wada, R. Shibuya, M. Nakamura, K. Yamaguchi, T. Yamazaki, T. Imai, Y. Asada, K. Matsuura, K. Sugamura, Y. Katori, K. Satoh, K. Tamai*, Humanized anti-CD271 monoclonal antibody exerts an anti-tumor effect by depleting cancer stem cells, Cancer Lett, 144-152, 461, 2019
M. Mochizuki, M. Nakamura, R. Sibuya, T. Okazaki, J. Abe, T. Nakagawa, S. Takahashi, T. Yamazaki, T. Imai, A. Takano, H. Ito, T. Yokose, Y. Miyagi, Y. Daigo, I. Sato, K. Satoh, K. Sugamura, K. Yamaguchi, K.Tamai*, CD271 is a negative prognostic factor and essential for cell proliferation in lung squamous cell carcinoma, Lab Invest, 1349-1362, 9, 99, 2019
J. Abe, N. Tanuma, M. Nomura, S. Ito, I. Kasugai, I. Sato, K. Tamai, M. Mochizuki, K. Yamaguchi, H. Shima, Y. Okada, J. Yasuda, Novel activating KRAS mutation candidates in lung adenocarcinoma, Biochem. Biophys. Res. Commun. (2019). https://doi.org/10.1016/j.bbrc.2019.11.151.
K. Okada, M. Araki, T. Sakashita, B. Ma, R. Kanada, N. Yanagitani, A. Horiike, S. Koike, T. Oh-Hara, K. Watanabe, K. Tamai, M. Maemondo, M. Nishio, T. Ishikawa, Y. Okuno, N. Fujita, R. Katayama, Prediction of ALK mutations mediating ALK-TKIs resistance and drug re-purposing to overcome the resistance, EBioMedicine, 2019
2018年
Y. Shimoyama, K. Tamai*, R. Shibuya, M. Nakamura, M. Mochizuki, K. Yamaguchi, Y. Kakuta, Y. Kinouchi, I. Sato, A. Kudo, T. Shimosegawa, K. Satoh, Periostin attenuates tumor growth by inducing apoptosis in colitis-related colorectal cancer, Oncotarget, 9 (2018) 20008-20017.
T. Okazaki, K. Tamai*, R. Shibuya, M. Nakamura, M. Mochizuki, K. Yamaguchi, J. Abe, S. Takahashi, I. Sato, A. Kudo, Y. Okada, K. Satoh, Periostin is a negative prognostic factor and promotes cancer cell proliferation in non-small cell lung cancer, Oncotarget (9) 31187-31199, 2018
M. Yokoyama, N. Tanuma, R. Shibuya, T. Shiroki, M. Abue, K. Yamamoto, K. Miura, K. Yamaguchi, I. Sato, K. Tamai, K. Satoh, Pyruvate kinase type M2 contributes to the development of pancreatic ductal adenocarcinoma by regulating the production of metabolites and reactive oxygen species, Int J Oncol (52) 881-891, 2018
Y. Fujisaka, T. Iwata, K. Tamai*, M. Nakamura, M. Mochizuki, R. Shibuya, K. Yamaguchi, T. Shimosegawa, K. Satoh, Long non-coding RNA HOTAIR up-regulates chemokine (C-C motif) ligand 2 and promotes proliferation of macrophages and myeloid-derived suppressor cells in hepatocellular carcinoma cell lines, Oncol Lett (15) 509-514, 2018
2017年
H. Katayama, K. Tamai*, R. Shibuya, M. Nakamura, M. Mochizuki, K. Yamaguchi, S. Kawamura, T. Tochigi, I. Sato, T. Okanishi, K. Sakurai, W. Fujibuchi, Y. Arai, K. Satoh, Long non-coding RNA HOTAIR promotes cell migration by upregulating insulin growth factor-binding protein 2 in renal cell carcinoma, Sci Rep (7) 12016, 2017
T. Shiroki, M. Yokoyama, N. Tanuma, R. Maejima, K. Tamai, K. Yamaguchi, T. Oikawa, T. Noguchi, K. Miura, T. Fujiya, H. Shima, I. Sato, N. Murata-Kamiya, M. Hatakeyama, K. Iijima, T. Shimosegawa, K. Satoh, The enhanced expression of PKM2 is involved in the gastric cancer development via regulating cancer specific metabolism, Cancer Sci, 2017
K. Nasu, K. Yamaguchi, T. Takanashi, K. Tamai, I. Sato, S. Ine, O. Sasaki, K. Satoh, N. Tanaka, Y. Tanaka, T. Fukushima, H. Harigae, K. Sugamura, Crucial role of carbonic anhydrase IX in tumorigenicity of xenotransplanted adult T-cell leukemia-derived cells, Cancer Sci, 2017
2016年
K. Yamaguchi, T. Takanashi, K. Nasu, K. Tamai, M. Mochizuki, I. Satoh, S. Ine, O. Sasaki, K. Satoh, N. Tanaka, H. Harigae, K. Sugamura, Xenotransplantation elicits salient tumorigenicity of adult T-cell leukemia-derived cells via aberrant AKT activation, Cancer Sci (107) 638-643, 2016
R. Oshima, T. Hasegawa, K. Tamai, N. Sugeno, S. Yoshida, J. Kobayashi, A. Kikuchi, T. Baba, A. Futatsugi, I. Sato, K. Satoh, A. Takeda, M. Aoki, N. Tanaka, ESCRT-0 dysfunction compromises autophagic degradation of protein aggregates and facilitates ER stress-mediated neurodegeneration via apoptotic and necroptotic pathways, Sci Rep (6) 24997, 2016
M. Mochizuki, K. Tamai*, T. Imai, S. Sugawara, N. Ogama, M. Nakamura, K. Matsuura, K. Yamaguchi, K. Satoh, I. Sato, H. Motohashi, K. Sugamura, N. Tanaka, CD271 regulates the proliferation and motility of hypopharyngeal cancer cells, Sci Rep (6) 30707, 2016
R. Maejima, K. Tamai, T. Shiroki, M. Yokoyama, R. Shibuya, M. Nakamura, K. Yamaguchi, M. Abue, T. Oikawa, T. Noguchi, K. Miura, T. Fujiya, I. Sato, K. Iijima, T. Shimosegawa, N. Tanaka, K. Satoh, Enhanced expression of semaphorin 3E is involved in the gastric cancer development, Int J Oncol (49) 887-894, 2016
S. Aoki, M. Mizuma, Y. Takahashi, Y. Haji, R. Okada, T. Abe, H. Karasawa, K. Tamai, T. Okada, T. Morikawa, H. Hayashi, K. Nakagawa, F. Motoi, T. Naitoh, Y. Katayose, M. Unno, Aberrant activation of Notch signaling in extrahepatic cholangiocarcinoma: clinicopathological features and therapeutic potential for cancer stem cell-like properties, BMC Cancer (16) 854, 2016
2015年以前
M. Abue, M. Yokoyama, R. Shibuya, K. Tamai, K. Yamaguchi, I. Sato, N. Tanaka, S. Hamada, T. Shimosegawa, K. Sugamura, K. Satoh, Circulating miR-483-3p and miR-21 is highly expressed in plasma of pancreatic cancer, Int J Oncol (46) 539-547, 2015
Z. Watanuki, H. Kosai, N. Osanai, N. Ogama, M. Mochizuki, K. Tamai, K. Yamaguchi, K. Satoh, T. Fukuhara, M. Maemondo, M. Ichinose, T. Nukiwa, N. Tanaka, Synergistic cytotoxicity of afatinib and cetuximab against EGFR T790M involves Rab11-dependent EGFR recycling, Biochem Biophys Res Commun (455) 269-276, 2014
K. Tamai*, M. Nakamura, M. Mizuma, M. Mochizuki, M. Yokoyama, H. Endo, K. Yamaguchi, T. Nakagawa, M. Shiina, M. Unno, K. Muramoto, I. Sato, K. Satoh, K. Sugamura, N. Tanaka, Suppressive expression of CD274 increases tumorigenesis and cancer stem cell phenotypes in cholangiocarcinoma, Cancer Sci (105) 667-674, 2014
T. Nagata, K. Murata, R. Murata, S.L. Sun, Y. Saito, S. Yamaga, N. Tanaka, K. Tamai, K. Moriya, N. Kasai, K. Sugamura, N. Ishii, Hepatocyte growth factor regulated tyrosine kinase substrate in the peripheral development and function of B-cells, Biochem Biophys Res Commun (443) 351-356, 2014
T. Nakagawa, H. Endo, M. Yokoyama, J. Abe, K. Tamai, N. Tanaka, I. Sato, S. Takahashi, T. Kondo, K. Satoh, Large noncoding RNA HOTAIR enhances aggressive biological behavior and is associated with short disease-free survival in human non-small cell lung cancer, Biochem Biophys Res Commun (436) 319-324, 2013
T. Imai, K. Tamai, S. Oizumi, K. Oyama, K. Yamaguchi, I. Sato, K. Satoh, K. Matsuura, S. Saijo, K. Sugamura, N. Tanaka, CD271 defines a stem cell-like population in hypopharyngeal cancer, PLoS One (8) e62002, 2013
H. Endo, T. Shiroki, T. Nakagawa, M. Yokoyama, K. Tamai, H. Yamanami, T. Fujiya, I. Sato, K. Yamaguchi, N. Tanaka, K. Iijima, T. Shimosegawa, K. Sugamura, K. Satoh, Enhanced expression of long non-coding RNA HOTAIR is associated with the development of gastric cancer, PLoS One (8) e77070, 2013
K. Tamai, M. Shiina, N. Tanaka, T. Nakano, A. Yamamoto, Y. Kondo, E. Kakazu, J. Inoue, K. Fukushima, K. Sano, Y. Ueno, T. Shimosegawa, K. Sugamura, Regulation of hepatitis C virus secretion by the Hrs-dependent exosomal pathway, Virology (422) 377-385, 2012
Y. Kondo, Y. Ueno, M. Ninomiya, K. Tamai, Y. Tanaka, J. Inoue, E. Kakazu, K. Kobayashi, O. Kimura, M. Miura, T. Yamamoto, T. Kobayashi, T. Igarashi, T. Shimosegawa, Sequential immunological analysis of HBV/HCV co-infected patients during Peg-IFN/RBV therapy, J Gastroenterol (47) 1323-1335, 2012
S. Suzuki, K. Tamai*, M. Watanabe, M. Kyuuma, M. Ono, K. Sugamura, N. Tanaka, AMSH is required to degrade ubiquitinated proteins in the central nervous system, Biochem Biophys Res Commun (408) 582-588, 2011
Y. Kondo, Y. Ueno, E. Kakazu, K. Kobayashi, M. Shiina, K. Tamai, K. Machida, J. Inoue, Y. Wakui, K. Fukushima, N. Obara, O. Kimura, T. Shimosegawa, Lymphotropic HCV strain can infect human primary naive CD4+ cells and affect their proliferation and IFN-gamma secretion activity, J Gastroenterol (46) 232-241, 2011
E. Kakazu, Y. Ueno, Y. Kondo, J. Inoue, M. Ninomiya, O. Kimura, Y. Wakui, K. Fukushima, K. Tamai, T. Shimosegawa, Plasma L-cystine/L-glutamate imbalance increases tumor necrosis factor-alpha from CD14+ circulating monocytes in patients with advanced cirrhosis, PLoS One (6) e23402, 2011
J. Inoue, Y. Ueno, Y. Wakui, H. Niitsuma, K. Fukushima, Y. Yamagiwa, M. Shiina, Y. Kondo, E. Kakazu, K. Tamai, N. Obara, T. Iwasaki, T. Shimosegawa, Four-year study of lamivudine and adefovir combination therapy in lamivudine-resistant hepatitis B patients: influence of hepatitis B virus genotype and resistance mutation pattern, J Viral Hepat (18) 206-215, 2011
T. Hasegawa, M. Konno, T. Baba, N. Sugeno, A. Kikuchi, M. Kobayashi, E. Miura, N. Tanaka, K. Tamai, K. Furukawa, H. Arai, F. Mori, K. Wakabayashi, M. Aoki, Y. Itoyama, A. Takeda, The AAA-ATPase VPS4 regulates extracellular secretion and lysosomal targeting of alpha-synuclein, PLoS One (6) e29460, 2011
K. Tamai, N. Tanaka, T. Nakano, E. Kakazu, Y. Kondo, J. Inoue, M. Shiina, K. Fukushima, T. Hoshino, K. Sano, Y. Ueno, T. Shimosegawa, K. Sugamura, Exosome secretion of dendritic cells is regulated by Hrs, an ESCRT-0 protein, Biochem Biophys Res Commun (399) 384-390, 2010
N. Obara, K. Fukushima, Y. Ueno, Y. Wakui, O. Kimura, K. Tamai, E. Kakazu, J. Inoue, Y. Kondo, N. Ogawa, K. Sato, T. Tsuduki, K. Ishida, T. Shimosegawa, Possible involvement and the mechanisms of excess trans-fatty acid consumption in severe NAFLD in mice, J Hepatol (53) 326-334, 2010
Y. Kondo, Y. Ueno, K. Kobayashi, E. Kakazu, M. Shiina, J. Inoue, K. Tamai, Y. Wakui, Y. Tanaka, M. Ninomiya, N. Obara, K. Fukushima, M. Ishii, T. Kobayashi, H. Niitsuma, S. Kon, T. Shimosegawa, Hepatitis B virus replication could enhance regulatory T cell activity by producing soluble heat shock protein 60 from hepatocytes, J Infect Dis (202) 202-213, 2010
E. Kakazu, Y. Ueno, Y. Kondo, K. Fukushima, M. Shiina, J. Inoue, K. Tamai, M. Ninomiya, T. Shimosegawa, Branched chain amino acids enhance the maturation and function of myeloid dendritic cells ex vivo in patients with advanced cirrhosis, Hepatology (50) 1936-1945, 2009
J. Inoue, Y. Ueno, F. Nagasaki, T. Akahane, K. Fukushima, T. Kogure, Y. Kondo, E. Kakazu, K. Tamai, O. Kido, Y. Nakagome, M. Ninomiya, N. Obara, Y. Wakui, M. Takahashi, H. Okamoto, T. Shimosegawa, Sporadic acute hepatitis E occurred constantly during the last decade in northeast Japan, J Gastroenterol (44) 329-337, 2009
K. Tamai, M. Toyoshima, N. Tanaka, N. Yamamoto, Y. Owada, H. Kiyonari, K. Murata, Y. Ueno, M. Ono, T. Shimosegawa, N. Yaegashi, M. Watanabe, K. Sugamura, Loss of hrs in the central nervous system causes accumulation of ubiquitinated proteins and neurodegeneration, Am J Pathol (173) 1806-1817, 2008
K. Tamai, N. Tanaka, A. Nara, A. Yamamoto, I. Nakagawa, T. Yoshimori, Y. Ueno, T. Shimosegawa, K. Sugamura, Role of Hrs in maturation of autophagosomes in mammalian cells, Biochem Biophys Res Commun (360) 721-727, 2007
K. Tamai, K. Fukushima, Y. Ueno, Y. Moritoki, Y. Yamagiwa, N. Kanno, D.M. Jefferson, T. Shimosegawa, Differential expressions of aquaporin proteins in human cholestatic liver diseases., Hepatol Res. 34 (2006) 99–103.
A. Nakashima, N. Tanaka, K. Tamai, M. Kyuuma, Y. Ishikawa, H. Sato, T. Yoshimori, S. Saito, K. Sugamura, Survival of parvovirus B19-infected cells by cellular autophagy., Virology. 349 (2006) 254–263.
