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発表論文リスト


発表論文リスト(英文)

2021年


  1. D. Fukushi, R. Shibuya-Takahashi, M. Mochizuki, H. Fujimori, T. Kogure, T. Sugai, W. Iwai, Y. Wakui, M. Abue, K. Murakami, Y. Nakamura, J. Yasuda, K. Yamaguchi, K. Sugamura, C. Shibata, Y. Katayose, K. Satoh,K. Tamai, BEX2 is required for maintaining dormant cancer stem cell in hepatocellular carcinoma, Cancer Sci. (2021). https://doi.org/10.1111/cas.15115.
  2. T. Minato, S. Ito, B. Li, H. Fujimori, M. Mochizuki, K. Yamaguchi, K. Tamai, M. Shimada, H. Tokunaga, S. Shigeta, I. Sato, H. Shima, H. Yamada, N. Yaegashi, J. Yasuda, Liquid biopsy with droplet digital PCR targeted to specific mutations in plasma cell-free tumor DNA can detect ovarian cancer recurrence earlier than CA125, Gynecologic Oncology Reports. (2021) 100847. https://doi.org/10.1016/j.gore.2021.100847.
  3. K. Kishimoto, K. Kanazawa, M. Nomura, T. Tanaka, T. Shigemoto-Kuroda, K. Fukui, K. Miura, K. Kurosawa, M. Kawai, H. Kato, K. Terasaki, Y. Sakamoto, Y. Yamashita, I. Sato, N. Tanuma,K. Tamai, I. Kitabayashi, K. Matsuura, T. Watanabe, J. Yasuda, H. Tsuji, H. Shima, Ppp6c deficiency accelerates K-rasG12D -induced tongue carcinogenesis, Cancer Med. 10 (2021) 4451–4464. https://doi.org/10.1002/cam4.3962.
  4. S. Saijoh, M. Nakamura-Shima, R. Shibuya-Takahashi, R. Ito, A. Sugawara, T. Yamazaki, T. Imai, Y. Asada, K. Matsuura, W. Iwai, Y. Wakui, M. Abue, S. Kawamura, Y. Katayose, H. Fujimori, M. Mochizuki, J. Yasuda, K. Yamaguchi, K. Sugamura, K. Satoh, Y. Katori, K. Tamai, Discovery of a chemical compound that suppresses expression of BEX2, a dormant cancer stem cell-related protein, Biochem Biophys Res Commun. 537 (2021) 132–139. https://doi.org/10.1016/j.bbrc.2020.11.022.
  5. H. Mizuta, K. Okada, M. Araki, J. Adachi, A. Takemoto, J. Kutkowska, K. Maruyama, N. Yanagitani, T. Oh-Hara, K. Watanabe, K. Tamai, L. Friboulet, K. Katayama, B. Ma, Y. Sasakura, Y. Sagae, M. Kukimoto-Niino, M. Shirouzu, S. Takagi, S. Simizu, M. Nishio, Y. Okuno, N. Fujita, R. Katayama, Gilteritinib overcomes lorlatinib resistance in ALK-rearranged cancer, Nat Commun. 12 (2021) 1261. https://doi.org/10.1038/s41467-021-21396-w.
  6. S. Ito, I. Sato, M. Mochizuki, K. Yamaguchi, K. Tamai, T. Minato, N. Tanuma, H. Shima, J. Yasuda, Robustness of a Cancer Profiling Test Using Formalin-fixed Paraffin Embedded Tumor Specimens, Anticancer Res. 41 (2021) 1341–1348. https://doi.org/10.21873/anticanres.14891.

2020年


  1. K. Tamai, M. Nakamura-Shima, R. Shibuya-Takahashi, S.-I. Kanno, A. Yasui, M. Mochizuki, W. Iwai, Y. Wakui, M. Abue, K. Yamamoto, K. Miura, M. Mizuma, M. Unno, S. Kawamura, I. Sato, J. Yasuda, K. Yamaguchi, K. Sugamura, K. Satoh, BEX2 suppresses mitochondrial activity and is required for dormant cancer stem cell maintenance in intrahepatic cholangiocarcinoma, Scientific Reports. 10 (2020) 21592. https://doi.org/10.1038/s41598-020-78539-0.
  2. Y. Hatsuzawa, K. Yamaguchi, T. Takanashi, I. Sato, K. Tamai, M. Mochizuki, W. Iwai, Y. Wakui, M. Abue, K. Yamamoto, J. Yasuda, M. Mizuma, M. Unno, K. Sugamura, CD109 promotes the tumorigenic ability and metastatic motility of pancreatic ductal adenocarcinoma cells, Pancreatology. 20 (2020) 493–500. https://doi.org/10.1016/j.pan.2020.01.013.
  3. S. Morita, M. Mochizuki, R. Shibuya-Takahashi, M. Nakamura-Shima, T. Yamazaki, T. Imai, Y. Asada, K. Matsuura, S. Kawamura, K. Yamaguchi, J. Yasuda, K. Sugamura, Y. Katori, K. Satoh, K. Tamai. Establishment of a monoclonal antibody that recognizes cysteine-rich domain 1 of human CD271. Monoclonal Antibodies in Immunodiagnosis and Immunotherapy, 39 (2020) 6-11

2019年


  1. S. Morita, M. Mochizuki, K. Wada, R. Shibuya, M. Nakamura, K. Yamaguchi, T. Yamazaki, T. Imai, Y. Asada, K. Matsuura, K. Sugamura, Y. Katori, K. Satoh, K. Tamai, Humanized anti-CD271 monoclonal antibody exerts an anti-tumor effect by depleting cancer stem cells, Cancer Lett, 144-152, 461, 2019

  2. M. Mochizuki, M. Nakamura, R. Sibuya, T. Okazaki, J. Abe, T. Nakagawa, S. Takahashi, T. Yamazaki, T. Imai, A. Takano, H. Ito, T. Yokose, Y. Miyagi, Y. Daigo, I. Sato, K. Satoh, K. Sugamura, K. Yamaguchi, K.Tamai, CD271 is a negative prognostic factor and essential for cell proliferation in lung squamous cell carcinoma, Lab Invest, 1349-1362, 9, 99, 2019

  3. J. Abe, N. Tanuma, M. Nomura, S. Ito, I. Kasugai, I. Sato, K. Tamai, M. Mochizuki, K. Yamaguchi, H. Shima, Y. Okada, J. Yasuda, Novel activating KRAS mutation candidates in lung adenocarcinoma, Biochem. Biophys. Res. Commun. (2019). https://doi.org/10.1016/j.bbrc.2019.11.151.

  4. K. Okada, M. Araki, T. Sakashita, B. Ma, R. Kanada, N. Yanagitani, A. Horiike, S. Koike, T. Oh-Hara, K. Watanabe, K. Tamai, M. Maemondo, M. Nishio, T. Ishikawa, Y. Okuno, N. Fujita, R. Katayama, Prediction of ALK mutations mediating ALK-TKIs resistance and drug re-purposing to overcome the resistance, EBioMedicine, 2019

2018年


  1. Y. Shimoyama, K. Tamai, R. Shibuya, M. Nakamura, M. Mochizuki, K. Yamaguchi, Y. Kakuta, Y. Kinouchi, I. Sato, A. Kudo, T. Shimosegawa, K. Satoh, Periostin attenuates tumor growth by inducing apoptosis in colitis-related colorectal cancer, Oncotarget, 9 (2018) 20008-20017.

  2. T. Okazaki, K. Tamai, R. Shibuya, M. Nakamura, M. Mochizuki, K. Yamaguchi, J. Abe, S. Takahashi, I. Sato, A. Kudo, Y. Okada, K. Satoh, Periostin is a negative prognostic factor and promotes cancer cell proliferation in non-small cell lung cancer, Oncotarget (9) 31187-31199, 2018

  3. M. Yokoyama, N. Tanuma, R. Shibuya, T. Shiroki, M. Abue, K. Yamamoto, K. Miura, K. Yamaguchi, I. Sato, K. Tamai, K. Satoh, Pyruvate kinase type M2 contributes to the development of pancreatic ductal adenocarcinoma by regulating the production of metabolites and reactive oxygen species, Int J Oncol (52) 881-891, 2018

  4. Y. Fujisaka, T. Iwata, K. Tamai, M. Nakamura, M. Mochizuki, R. Shibuya, K. Yamaguchi, T. Shimosegawa, K. Satoh, Long non-coding RNA HOTAIR up-regulates chemokine (C-C motif) ligand 2 and promotes proliferation of macrophages and myeloid-derived suppressor cells in hepatocellular carcinoma cell lines, Oncol Lett (15) 509-514, 2018

2017年


  1. H. Katayama, K. Tamai, R. Shibuya, M. Nakamura, M. Mochizuki, K. Yamaguchi, S. Kawamura, T. Tochigi, I. Sato, T. Okanishi, K. Sakurai, W. Fujibuchi, Y. Arai, K. Satoh, Long non-coding RNA HOTAIR promotes cell migration by upregulating insulin growth factor-binding protein 2 in renal cell carcinoma, Sci Rep (7) 12016, 2017

  2. T. Shiroki, M. Yokoyama, N. Tanuma, R. Maejima, K. Tamai, K. Yamaguchi, T. Oikawa, T. Noguchi, K. Miura, T. Fujiya, H. Shima, I. Sato, N. Murata-Kamiya, M. Hatakeyama, K. Iijima, T. Shimosegawa, K. Satoh, The enhanced expression of PKM2 is involved in the gastric cancer development via regulating cancer specific metabolism, Cancer Sci, 2017

  3. K. Nasu, K. Yamaguchi, T. Takanashi, K. Tamai, I. Sato, S. Ine, O. Sasaki, K. Satoh, N. Tanaka, Y. Tanaka, T. Fukushima, H. Harigae, K. Sugamura, Crucial role of carbonic anhydrase IX in tumorigenicity of xenotransplanted adult T-cell leukemia-derived cells, Cancer Sci, 2017

2016年


  1. K. Yamaguchi, T. Takanashi, K. Nasu, K. Tamai, M. Mochizuki, I. Satoh, S. Ine, O. Sasaki, K. Satoh, N. Tanaka, H. Harigae, K. Sugamura, Xenotransplantation elicits salient tumorigenicity of adult T-cell leukemia-derived cells via aberrant AKT activation, Cancer Sci (107) 638-643, 2016

  2. R. Oshima, T. Hasegawa, K. Tamai, N. Sugeno, S. Yoshida, J. Kobayashi, A. Kikuchi, T. Baba, A. Futatsugi, I. Sato, K. Satoh, A. Takeda, M. Aoki, N. Tanaka, ESCRT-0 dysfunction compromises autophagic degradation of protein aggregates and facilitates ER stress-mediated neurodegeneration via apoptotic and necroptotic pathways, Sci Rep (6) 24997, 2016

  3. M. Mochizuki, K. Tamai, T. Imai, S. Sugawara, N. Ogama, M. Nakamura, K. Matsuura, K. Yamaguchi, K. Satoh, I. Sato, H. Motohashi, K. Sugamura, N. Tanaka, CD271 regulates the proliferation and motility of hypopharyngeal cancer cells, Sci Rep (6) 30707, 2016

  4. R. Maejima, K. Tamai, T. Shiroki, M. Yokoyama, R. Shibuya, M. Nakamura, K. Yamaguchi, M. Abue, T. Oikawa, T. Noguchi, K. Miura, T. Fujiya, I. Sato, K. Iijima, T. Shimosegawa, N. Tanaka, K. Satoh, Enhanced expression of semaphorin 3E is involved in the gastric cancer development, Int J Oncol (49) 887-894, 2016

  5. S. Aoki, M. Mizuma, Y. Takahashi, Y. Haji, R. Okada, T. Abe, H. Karasawa, K. Tamai, T. Okada, T. Morikawa, H. Hayashi, K. Nakagawa, F. Motoi, T. Naitoh, Y. Katayose, M. Unno, Aberrant activation of Notch signaling in extrahepatic cholangiocarcinoma: clinicopathological features and therapeutic potential for cancer stem cell-like properties, BMC Cancer (16) 854, 2016

2015年以前


  1. M. Abue, M. Yokoyama, R. Shibuya, K. Tamai, K. Yamaguchi, I. Sato, N. Tanaka, S. Hamada, T. Shimosegawa, K. Sugamura, K. Satoh, Circulating miR-483-3p and miR-21 is highly expressed in plasma of pancreatic cancer, Int J Oncol (46) 539-547, 2015

  2. Z. Watanuki, H. Kosai, N. Osanai, N. Ogama, M. Mochizuki, K. Tamai, K. Yamaguchi, K. Satoh, T. Fukuhara, M. Maemondo, M. Ichinose, T. Nukiwa, N. Tanaka, Synergistic cytotoxicity of afatinib and cetuximab against EGFR T790M involves Rab11-dependent EGFR recycling, Biochem Biophys Res Commun (455) 269-276, 2014

  3. K. Tamai, M. Nakamura, M. Mizuma, M. Mochizuki, M. Yokoyama, H. Endo, K. Yamaguchi, T. Nakagawa, M. Shiina, M. Unno, K. Muramoto, I. Sato, K. Satoh, K. Sugamura, N. Tanaka, Suppressive expression of CD274 increases tumorigenesis and cancer stem cell phenotypes in cholangiocarcinoma, Cancer Sci (105) 667-674, 2014

  4. T. Nagata, K. Murata, R. Murata, S.L. Sun, Y. Saito, S. Yamaga, N. Tanaka, K. Tamai, K. Moriya, N. Kasai, K. Sugamura, N. Ishii, Hepatocyte growth factor regulated tyrosine kinase substrate in the peripheral development and function of B-cells, Biochem Biophys Res Commun (443) 351-356, 2014

  5. T. Nakagawa, H. Endo, M. Yokoyama, J. Abe, K. Tamai, N. Tanaka, I. Sato, S. Takahashi, T. Kondo, K. Satoh, Large noncoding RNA HOTAIR enhances aggressive biological behavior and is associated with short disease-free survival in human non-small cell lung cancer, Biochem Biophys Res Commun (436) 319-324, 2013

  6. T. Imai, K. Tamai, S. Oizumi, K. Oyama, K. Yamaguchi, I. Sato, K. Satoh, K. Matsuura, S. Saijo, K. Sugamura, N. Tanaka, CD271 defines a stem cell-like population in hypopharyngeal cancer, PLoS One (8) e62002, 2013

  7. H. Endo, T. Shiroki, T. Nakagawa, M. Yokoyama, K. Tamai, H. Yamanami, T. Fujiya, I. Sato, K. Yamaguchi, N. Tanaka, K. Iijima, T. Shimosegawa, K. Sugamura, K. Satoh, Enhanced expression of long non-coding RNA HOTAIR is associated with the development of gastric cancer, PLoS One (8) e77070, 2013

  8. K. Tamai, M. Shiina, N. Tanaka, T. Nakano, A. Yamamoto, Y. Kondo, E. Kakazu, J. Inoue, K. Fukushima, K. Sano, Y. Ueno, T. Shimosegawa, K. Sugamura, Regulation of hepatitis C virus secretion by the Hrs-dependent exosomal pathway, Virology (422) 377-385, 2012

  9. Y. Kondo, Y. Ueno, M. Ninomiya, K. Tamai, Y. Tanaka, J. Inoue, E. Kakazu, K. Kobayashi, O. Kimura, M. Miura, T. Yamamoto, T. Kobayashi, T. Igarashi, T. Shimosegawa, Sequential immunological analysis of HBV/HCV co-infected patients during Peg-IFN/RBV therapy, J Gastroenterol (47) 1323-1335, 2012

  10. S. Suzuki, K. Tamai, M. Watanabe, M. Kyuuma, M. Ono, K. Sugamura, N. Tanaka, AMSH is required to degrade ubiquitinated proteins in the central nervous system, Biochem Biophys Res Commun (408) 582-588, 2011

  11. Y. Kondo, Y. Ueno, E. Kakazu, K. Kobayashi, M. Shiina, K. Tamai, K. Machida, J. Inoue, Y. Wakui, K. Fukushima, N. Obara, O. Kimura, T. Shimosegawa, Lymphotropic HCV strain can infect human primary naive CD4+ cells and affect their proliferation and IFN-gamma secretion activity, J Gastroenterol (46) 232-241, 2011

  12. E. Kakazu, Y. Ueno, Y. Kondo, J. Inoue, M. Ninomiya, O. Kimura, Y. Wakui, K. Fukushima, K. Tamai, T. Shimosegawa, Plasma L-cystine/L-glutamate imbalance increases tumor necrosis factor-alpha from CD14+ circulating monocytes in patients with advanced cirrhosis, PLoS One (6) e23402, 2011

  13. J. Inoue, Y. Ueno, Y. Wakui, H. Niitsuma, K. Fukushima, Y. Yamagiwa, M. Shiina, Y. Kondo, E. Kakazu, K. Tamai, N. Obara, T. Iwasaki, T. Shimosegawa, Four-year study of lamivudine and adefovir combination therapy in lamivudine-resistant hepatitis B patients: influence of hepatitis B virus genotype and resistance mutation pattern, J Viral Hepat (18) 206-215, 2011

  14. T. Hasegawa, M. Konno, T. Baba, N. Sugeno, A. Kikuchi, M. Kobayashi, E. Miura, N. Tanaka, K. Tamai, K. Furukawa, H. Arai, F. Mori, K. Wakabayashi, M. Aoki, Y. Itoyama, A. Takeda, The AAA-ATPase VPS4 regulates extracellular secretion and lysosomal targeting of alpha-synuclein, PLoS One (6) e29460, 2011

  15. K. Tamai, N. Tanaka, T. Nakano, E. Kakazu, Y. Kondo, J. Inoue, M. Shiina, K. Fukushima, T. Hoshino, K. Sano, Y. Ueno, T. Shimosegawa, K. Sugamura, Exosome secretion of dendritic cells is regulated by Hrs, an ESCRT-0 protein, Biochem Biophys Res Commun (399) 384-390, 2010

  16. N. Obara, K. Fukushima, Y. Ueno, Y. Wakui, O. Kimura, K. Tamai, E. Kakazu, J. Inoue, Y. Kondo, N. Ogawa, K. Sato, T. Tsuduki, K. Ishida, T. Shimosegawa, Possible involvement and the mechanisms of excess trans-fatty acid consumption in severe NAFLD in mice, J Hepatol (53) 326-334, 2010

  17. Y. Kondo, Y. Ueno, K. Kobayashi, E. Kakazu, M. Shiina, J. Inoue, K. Tamai, Y. Wakui, Y. Tanaka, M. Ninomiya, N. Obara, K. Fukushima, M. Ishii, T. Kobayashi, H. Niitsuma, S. Kon, T. Shimosegawa, Hepatitis B virus replication could enhance regulatory T cell activity by producing soluble heat shock protein 60 from hepatocytes, J Infect Dis (202) 202-213, 2010

  18. E. Kakazu, Y. Ueno, Y. Kondo, K. Fukushima, M. Shiina, J. Inoue, K. Tamai, M. Ninomiya, T. Shimosegawa, Branched chain amino acids enhance the maturation and function of myeloid dendritic cells ex vivo in patients with advanced cirrhosis, Hepatology (50) 1936-1945, 2009

  19. J. Inoue, Y. Ueno, F. Nagasaki, T. Akahane, K. Fukushima, T. Kogure, Y. Kondo, E. Kakazu, K. Tamai, O. Kido, Y. Nakagome, M. Ninomiya, N. Obara, Y. Wakui, M. Takahashi, H. Okamoto, T. Shimosegawa, Sporadic acute hepatitis E occurred constantly during the last decade in northeast Japan, J Gastroenterol (44) 329-337, 2009

  20. K. Tamai, M. Toyoshima, N. Tanaka, N. Yamamoto, Y. Owada, H. Kiyonari, K. Murata, Y. Ueno, M. Ono, T. Shimosegawa, N. Yaegashi, M. Watanabe, K. Sugamura, Loss of hrs in the central nervous system causes accumulation of ubiquitinated proteins and neurodegeneration, Am J Pathol (173) 1806-1817, 2008

  21. K. Tamai, N. Tanaka, A. Nara, A. Yamamoto, I. Nakagawa, T. Yoshimori, Y. Ueno, T. Shimosegawa, K. Sugamura, Role of Hrs in maturation of autophagosomes in mammalian cells, Biochem Biophys Res Commun (360) 721-727, 2007

  22. K. Tamai, K. Fukushima, Y. Ueno, Y. Moritoki, Y. Yamagiwa, N. Kanno, D.M. Jefferson, T. Shimosegawa, Differential expressions of aquaporin proteins in human cholestatic liver diseases., Hepatol Res. 34 (2006) 99–103.
  23. A. Nakashima, N. Tanaka, K. Tamai, M. Kyuuma, Y. Ishikawa, H. Sato, T. Yoshimori, S. Saito, K. Sugamura, Survival of parvovirus B19-infected cells by cellular autophagy., Virology. 349 (2006) 254–263.

発表論文リスト(邦文)

  1. 玉井 恵一、上野 義之、涌井 祐太、小原 範之、嘉数 英二、井上 淳、近藤 泰輝、山極 洋子、椎名 正明、福島 耕治、岩崎 隆雄、下瀬川 徹
    HCV感染における小胞輸送経路ESCRTの役割
    消化器と免疫 46号 Page206-210

  2. 玉井恵一、佐藤賢一
    がん幹細胞における上皮間葉転換と静止期維持
    次世代のがん治療薬・診断のための研究開発,2016年2月発刊