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発表論文リスト


2021年

  • Sakurai-Yageta M, Kumada K, Gocho C, Makino S, Uruno A, Tadaka S, Motoike IN, Kimura M, Ito S, Otsuki A, Narita A, Kudo H, Aoki Y, Danjoh I, Yasuda J, Kawame H, Minegishi N, Koshiba S, Fuse N, Tamiya G, Yamamoto M, Kinoshita K. Japonica Array NEO with increased genome-wide coverage and abundant disease risk SNPs. J Biochem. 2021 May 13:mvab060. doi: 10.1093/jb/mvab060.

    • Ito S, Sato I, Mochizuki M, Yamaguchi K, Tamai K, Minato T, Tanuma N, Shima H and Yasuda J. Robustness of a Cancer Profiling Test Using Formalin-fixed Paraffin Embedded Tumor Specimens. Anticancer Res. 2021 March;41(3):1341-1348. doi:10.21873/anticanres.14891.


      • Yajima M, Kakuta R, Saito Y, Kitaya S, Toyoda A, Ikuta K, Yasuda J, Ohta N, Kanda T., A global phylogenetic analysis of Japanese tonsil-derived Epstein-Barr virus strains using viral whole-genome cloning and long-read sequencing. J Gen Virol. 2021 Jan 12. doi: 10.1099/jgv.0.001549.


        • Takayama J, Tadaka S, Yano K, Katsuoka F, Gocho C, Funayama T, Makino S, Okamura Y, Kikuchi A, Sugimoto S, Kawashima J, Otsuki A, Sakurai-Yageta M, Yasuda J, Kure S, Kinoshita K, Yamamoto M, Tamiya G. Construction and integration of three de novo Japanese human genome assemblies toward a population-specific reference. Nat Commun. 2021 Jan 11;12(1):226. doi: 10.1038/s41467-020-20146-8.


          • Tokunaga H, Iida K, Hozawa A, Ogishima S, Watanabe Y, Shigeta S, Shimada M, Yamaguchi-Kabata Y, Tadaka S, Katsuoka F, Ito S, Kumada K, Hamanaka Y, Fuse N, Kinoshita K, Yamamoto M, Yaegashi N, Yasuda J. Novel candidates of pathogenic variants of the BRCA1 and BRCA2 genes from a dataset of 3,552 Japanese whole genomes (3.5KJPNv2). PLoS One. 2021 Jan 11;16(1):e0236907. doi: 10.1371/journal.pone.0236907. eCollection 2021.


            • Saijoh S, Nakamura-Shima M, Shibuya-Takahashi R, Ito R, Sugawara A, Yamazaki T, Imai T, Asada Y, Matsuura K, Iwai W, Wakui Y, Abue M, Kawamura S, Katayose Y, Fujimori H, Mochizuki M, Yasuda J, Yamaguchi K, Sugamura K,Satoh K, Katori Y, Tamai K., Discovery of a chemical compound that suppresses expression of BEX2, a dormant cancer stem cell-related protein. Biochem Biophys Res Commun. 2021 Jan 4;537:132-139. doi: 10.1016/j.bbrc.2020.11.022.

2020年

  • Tamai K, Nakamura-Shima M, Shibuya-Takahashi R, Kanno SI, Yasui A, Mochizuki M, Iwai W, Wakui Y, Abue M, Yamamoto K, Miura K, Mizuma M, Unno M, Kawamura S, Sato I, Yasuda J, Yamaguchi K, Sugamura K, Satoh K., BEX2 suppresses mitochondrial activity and is required for dormant cancer stem cell maintenance in intrahepatic cholangiocarcinoma. Sci Rep. 2020 Dec 9;10(1):21592. doi: 10.1038/s41598-020-78539-0.

    • Shibayama Y, Takahashi K, Yamaguchi H, Yasuda J, Yamazaki D, Rahman A, Fujimori T, Fujisawa Y, Takai S, Furukawa T, Nakagawa T, Ohsaki H, Kobara H, Wong JH, Masaki T, Yuzawa Y, Kiyomoto H, Yachida S, Fujimoto A, Nishiyama A. Aberrant (pro)renin receptor expression induces genomic instability in pancreatic ductal adenocarcinoma through upregulation of SMARCA5/SNF2H. Commun Biol. 2020 Nov 27;3(1):724. doi: 10.1038/s42003-020-01434-x.

      • Nishizawa A, Kumada K, Tateno K, Wagata M, Saito S, Katsuoka F, Mizuno S, Ogishima S, Yamamoto M, Yasuda J, Sugawara J. Analysis of HLA-G long-read genomic sequences in mother-offspring pairs with preeclampsia. Sci Rep. 2020 Nov 18;10(1):20027. doi: 10.1038/s41598-020-77081-3.

        • Yaoita N, Satoh K, Satoh T, Shimizu T, Saito S, Sugimura K, Tatebe S, Yamamoto S, Aoki T, Kikuchi N, Kurosawa R, Miyata S, Nagasaki M, Yasuda J, Shimokawa H. Identification of the Novel Variants in Patients With Chronic Thromboembolic Pulmonary Hypertension. J Am Heart Assoc. 2020 Nov 3;9(21):e015902. doi: 10.1161/JAHA.120.015902. Epub 2020 Oct 24.

          • Mori M, Hira A, Yoshida K, Muramatsu H, Okuno Y, Shiraishi Y, Anmae M, Yasuda J, Tadaka S, Kinoshita K, Osumi T, Noguchi Y, Adachi S, Kobayashi R, Kawabata H, Imai K, Morio T, Tamura K, Takaori-Kondo A, Yamamoto M, Miyano S, Kojima S, Ito E, Ogawa S, Matsuo K, Yabe H, Yabe M, Takata M. Pathogenic mutations identified by a multimodality approach in 117 Japanese Fanconi anemia patients. Haematologica. 2020 Apr;105(4):1166-1167. doi: 10.3324/haematol.2019.245720.

            • Morita S, Mochizuki M, Shibuya-Takahashi R, Nakamura-Shima M, Yamazaki T, Imai T, Asada Y, Matsuura K, Kawamura S, Yamaguchi K, Yasuda J, Sugamura K, Katori Y, Satoh K, Tamai K. Establishment of a Monoclonal Antibody That Recognizes Cysteine-Rich Domain 1 of Human CD271. Monoclon Antib Immunodiagn Immunother. 2020 Feb;39(1):6-11. doi: 10.1089/mab.2019.0040.

              • Kuriyama S, Metoki H, Kikuya M, Obara T, Ishikuro M, Yamanaka C, Nagai M, Matsubara H, Kobayashi T, Sugawara J, Tamiya G, Hozawa A, Nakaya N, Tsuchiya N, Nakamura T, Narita A, Kogure M, Hirata T, Tsuji I, Nagami F, Fuse N, Arai T, Kawaguchi Y, Higuchi S, Sakaida M, Suzuki Y, Osumi N, Nakayama K, Ito K, Egawa S, Chida K, Kodama E, Kiyomoto H, Ishii T, Tsuboi A, Tomita H, Taki Y, Kawame H, Suzuki K, Ishii N, Ogishima S, Mizuno S, Takai-Igarashi T, Minegishi N, Yasuda J, Igarashi K, Shimizu R, Nagasaki M, Tanabe O, Koshiba S, Hashizume H, Motohashi H, Tominaga T, Ito S, Tanno K, Sakata K, Shimizu A, Hitomi J, Sasaki M, Kinoshita K, Tanaka H, Kobayashi T; Tohoku Medical Megabank Project Study Group, Kure S, Yaegashi N, Yamamoto M. Cohort Profile: Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study (TMM BirThree Cohort Study): rationale, progress and perspective. Int J Epidemiol. 2020 Feb 1;49(1):18-19m. doi: 10.1093/ije/dyz169.

                • Takahashi Y, Takeuchi H, Sakai M, Yu Z, Kikuchi Y, Ito F, Matsuoka H, Tanabe O, Yasuda J, Taki Y, Kawashima R, Tomita H., A single nucleotide polymorphism (-250 A/C) of the GFAP gene is associated with brain structures and cerebral blood flow. Psychiatry Clin Neurosci. 2020 Jan;74(1):49-55. doi: 10.1111/pcn.12932. Epub 2019 Oct 16.

                  • Abe J, Tanuma N, Nomura M, Ito S, Kasugai I, Sato I, Tamai K, Mochizuki M, Yamaguchi K, Shima H, Okada Y, Yasuda J, Novel activating KRAS mutation candidates in lung adenocarcinoma, Biochem Biophys Res Commun. 2020 Feb 12;522(3):690-696. doi: 10.1016/j.bbrc.2019.11.151. Epub 2019 Nov 28.

                    • Hatsuzawa Y, Yamaguchi K, Takanashi T, Sato I, Tamai K, Mochizuki M, Iwai W, Wakui Y, Abue M, Yamamoto K, Yasuda J, Mizuma M, Unno M, Sugamura K, CD109 promotes the tumorigenic ability and metastatic motility of pancreatic ductal adenocarcinoma cells, Pancreatology. 2020 Apr;20(3):493-500. doi: 10.1016/j.pan.2020.01.013. Epub 2020 Jan 22.

                      • Hozawa A, Tanno K, Nakaya N, Nakamura T, Tsuchiya N, Hirata T, Narita A, Kogure M, Nochioka K, Sasaki R, Takanashi N, Otsuka K, Sakata K, Kuriyama S, Kikuya M, Tanabe O, Sugawara J, Suzuki K, Suzuki Y, Kodama EN, Fuse N, Kiyomoto H, Tomita H, Uruno A, Hamanaka Y, Metoki H, Ishikuro M, Obara T, Kobayashi T, Kitatani K, Takai-Igarashi T, Ogishima S, Satoh M, Ohmomo H, Tsuboi A, Egawa S, Ishii T, Ito K, Ito S, Taki Y, Minegishi N, Ishii N, Nagasaki M, Igarashi K, Koshiba S, Shimizu R, Tamiya G, Nakayama K, Motohashi H, Yasuda J, Shimizu A, Hachiya T, Shiwa Y, Tominaga T, Tanaka H, Oyama K, Tanaka R, Kawame H, Fukushima A, Ishigaki Y, Tokutomi T, Osumi N, Kobayashi T, Nagami F, Hashizume H, Arai T, Kawaguchi Y, Higuchi S, Sakaida M, Endo R, Nishizuka S, Tsuji I, Hitomi J, Nakamura M, Ogasawara K, Yaegashi N, Kinoshita K, Kure S, Sakai A, Kobayashi S, Sobue K, Sasaki M, Yamamoto M, Study profile of The Tohoku Medical Megabank Community-Based Cohort Study, J Epidemiol. 2020 Jan 11. doi: 10.2188/jea.JE20190271.

2019年

  • Katsuoka F, Otsuki A, Takahashi M, Ito S, Yamamoto M, Direct and Specific Functional Evaluation of the Nrf2 and MafG Heterodimer by Introducing a Tethered Dimer into Small Maf-Deficient Cells. Mol Cell Biol. 2019 Sep 27;39(20). pii: e00273-19. doi: 10.1128/MCB.00273-19. Print 2019 Oct 15

    • Mori M, Hira A, Yoshida K, Muramatsu H, Okuno Y, Shiraishi Y, Anmae M, Yasuda J, Tadaka S, Kinoshita K, Osumi T, Noguchi Y, Adachi S, Kobayashi R, Kawabata H, Imai K, Morio T, Tamura K, Takaori-Kondo A, Yamamoto M, Miyano S, Kojima S, Ito E, Ogawa S, Matsuo K, Yabe H, Yabe M, Takata M. Pathogenic mutations identified by a multimodality approach in 117 Japanese Fanconi anemia patients. Haematologica. 2019 Oct;104(10):1962-1973. doi: 10.3324/haematol.2018.207241. Epub 2019 Feb 21. PubMed PMID: 30792206.

      • Kakuta Y, Kawai Y, Naito T, Hirano A, Umeno J, Fuyuno Y, Liu Z, Li D, Nakano T, Izumiyama Y, Ichikawa R, Okamoto D, Nagai H, Matsumoto S, Yamamoto K, Yokoyama N, Chiba H, Shimoyama Y, Onodera M, Moroi R, Kuroha M, Kanazawa Y, Kimura T, Shiga H, Endo K, Negoro K, Yasuda J, Esaki M, Tokunaga K, Nakamura M, Matsumoto T, McGovern DPB, Nagasaki M, Kinouchi Y, Shimosegawa T, Masamune A. A Genome-wide Association Study Identifying RAP1A as a Novel Susceptibility Gene for Crohn's Disease in Japanese Individuals. J Crohns Colitis. 2019 Apr 26;13(5):648-658. doi: 10.1093/ecco-jcc/jjy197. PubMed PMID: 30500874.

        • Yasuda J, Kinoshita K, Katsuoka F, Danjoh I, Sakurai-Yageta M, Motoike IN, Kuroki Y, Saito S, Kojima K, Shirota M, Saigusa D, Otsuki A, Kawashima J, Yamaguchi-Kabata Y, Tadaka S, Aoki Y, Mimori T, Kumada K, Inoue J, Makino S, Kuriki M, Fuse N, Koshiba S, Tanabe O, Nagasaki M, Tamiya G, Shimizu R,Takai-Igarashi T, Ogishima S, Hozawa A, Kuriyama S, Sugawara J, Tsuboi A, Kiyomoto H, Ishii T, Tomita H, Minegishi N, Suzuki Y, Suzuki K, Kawame H, Tanaka H, Taki Y, Yaegashi N, Kure S, Nagami F; Tohoku Medical Megabank Project Study Group, Kosaki K, Sutoh Y, Hachiya T, Shimizu A, Sasaki M, Yamamoto M. Genome analyses for the Tohoku Medical Megabank Project towards establishment of personalized healthcare. J Biochem. 2019 Feb 1;165(2):139-158. doi:10.1093/jb/mvy096. PubMed PMID: 30452759.

          • Abe J, Tanuma N, Nomura M, Ito S, Kasugai I, Sato I, Tamai K, Mochizuki M, Yamaguchi K, Shima H, Okada Y, Yasuda J. Novel activating KRAS mutation candidates in lung adenocarcinoma. Biochem Biophys Res Commun. 2019 Nov 28. pii: S0006-291X(19)32279-X. doi:10.1016/j.bbrc.2019.11.151. [Epub ahead of print] PubMed PMID: 31787238.

            • Kuriyama S, Metoki H, Kikuya M, Obara T, Ishikuro M, Yamanaka C, Nagai M, Matsubara H, Kobayashi T, Sugawara J, Tamiya G, Hozawa A, Nakaya N, Tsuchiya N, Nakamura T, Narita A, Kogure M, Hirata T, Tsuji I, Nagami F, Fuse N, Arai T, Kawaguchi Y, Higuchi S, Sakaida M, Suzuki Y, Osumi N, Nakayama K, Ito K, Egawa S, Chida K, Kodama E, Kiyomoto H, Ishii T, Tsuboi A, Tomita H, Taki Y, Kawame H, Suzuki K, Ishii N, Ogishima S, Mizuno S, Takai-Igarashi T, Minegishi N, Yasuda J, Igarashi K, Shimizu R, Nagasaki M, Tanabe O, Koshiba S, Hashizume H, Motohashi H, Tominaga T, Ito S, Tanno K, Sakata K, Shimizu A, Hitomi J, Sasaki M, Kinoshita K, Tanaka H, Kobayashi T, Kure S, Yaegashi N, Yamamoto M; Tohoku Medical Megabank Project Study Group . Cohort Profile: Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study (TMM BirThree Cohort Study): Rationale, Progress and Perspective. Int J Epidemiol. 2019 Aug 25. pii: dyz169. doi:10.1093/ije/dyz169. [Epub ahead of print] PubMed PMID: 31504573.

              • Amano Y, Akazawa Y, Yasuda J, Yoshino K, Kojima K, Kobayashi N, Matsuzaki S, Nagasaki M, Kawai Y, Minegishi N, Ishida N, Motoki N, Hachiya A, Nakazawa Y, Yamamoto M, Koike K, Takeshita T. A low-frequency IL4R locus variant in Japanese patients with intravenous immunoglobulin therapy-unresponsive Kawasaki disease.
                Pediatr Rheumatol Online J. 2019 Jul 3;17(1):34. doi:10.1186/s12969-019-0337-2.
                PubMed PMID: 31269967; PubMed Central PMCID: PMC6610867.

                • Tadaka S, Katsuoka F, Ueki M, Kojima K, Makino S, Saito S, Otsuki A, Gocho C, Sakurai-Yageta M, Danjoh I, Motoike IN, Yamaguchi-Kabata Y, Shirota M, Koshiba S, Nagasaki M, Minegishi N, Hozawa A, Kuriyama S, Shimizu A, Yasuda J, Fuse N; Tohoku Medical Megabank Project Study Group, Tamiya G, Yamamoto M, Kinoshita K. 3.5KJPNv2: an allele frequency panel of 3552 Japanese individuals including the X chromosome. Hum Genome Var. 2019 Jun 18;6:28. doi:10.1038/s41439-019-0059-5. eCollection 2019. PubMed PMID: 31240104; PubMed Central PMCID: PMC6581902.

                  • Nagasaki M, Kuroki Y, Shibata TF, Katsuoka F, Mimori T, Kawai Y, Minegishi N, Hozawa A, Kuriyama S, Suzuki Y, Kawame H, Nagami F, Takai-Igarashi T, Ogishima S, Kojima K, Misawa K, Tanabe O, Fuse N, Tanaka H, Yaegashi N, Kinoshita K, Kure S, Yasuda J, Yamamoto M. Construction of JRG (Japanese reference genome) with single-molecule real-time sequencing. Hum Genome Var. 2019 Jun 7;6:27. doi:10.1038/s41439-019-0057-7. eCollection 2019. PubMed PMID: 31231536;
                    PubMed Central PMCID: PMC6555796.

                    • Kiniwa Y, Yasuda J, Saito S, Saito R, Motoike IN, Danjoh I, Kinoshita K, Fuse N, Yamamoto M, Okuyama R. Identification of genetic alterations in extramammary Paget disease using whole exome analysis. J Dermatol Sci. 2019 Apr;94(1):229-235. doi: 10.1016/j.jdermsci.2019.03.006. Epub 2019 Apr 11. PubMed PMID: 31023612.

                      • Yamaguchi-Kabata Y, Yasuda J, Uruno A, Shimokawa K, Koshiba S, Suzuki Y, Fuse N, Kawame H, Tadaka S, Nagasaki M, Kojima K, Katsuoka F, Kumada K, Tanabe O, Tamiya G, Yaegashi N, Kinoshita K, Yamamoto M, Kure S; Tohoku Medical Megabank Project Study Group. Estimating carrier frequencies of newborn screening disorders using a whole-genome reference panel of 3552 Japanese individuals. Hum Genet. 2019 Apr;138(4):389-409. doi: 10.1007/s00439-019-01998-7. Epub 2019 Mar 18. PubMed PMID: 30887117.

2018年

  • Shibuya, Y, Tokunaga, H, Saito, S, Shimokawa, K, Katsuoka, F, Bin, L, Kojima, K, Nagasaki, M, Yamamoto, M, Yaegashi, N,Yasuda, J, Identification of somatic genetic alterations in ovarian clear cell carcinoma with next generation sequencing, Genes Chromosomes Cancer, 57, 2, 51-60, 2018

  • Mimori, T, Yasuda, J, Kuroki, Y, Shibata, TF, Katsuoka, F, Saito, S, Nariai, N, Ono, A, Nakai-Inagaki, N, Misawa, K, Tateno, K, Kawai, Y, Fuse, N, Hozawa, A, Kuriyama, S, Sugawara, J, Minegishi, N, Suzuki, K, Kinoshita, K, Nagasaki, M and Yamamoto, M, Construction of full-length Japanese reference panel of class I HLA genes with single-molecule, real-time sequencing, Pharmacogenomics J, 2018

  • Yamaguchi-Kabata, Y, Yasuda, J, Tanabe, O, Suzuki, Y, Kawame, H, Fuse, N, Nagasaki, M, Kawai, Y, Kojima, K, Katsuoka, F, Saito, S, Danjoh, I, Motoike, IN, Yamashita, R, Koshiba, S, Saigusa, D, Tamiya, G, Kure, S, Yaegashi, N, Kawaguchi, Y, Nagami, F, Kuriyama, S, Sugawara, J, Minegishi, N, Hozawa, A, Ogishima, S, Kiyomoto, H, Takai-Igarashi, T, ToMMo Study Group, Kinoshita, K and Yamamoto, M, Evaluation of reported pathogenic variants and their frequencies in a Japanese population based on a whole-genome reference panel of 2049 individuals, J Hum Genet, 63, 2, 213-230, 2018

  • Tanikawa, C, Kamatani,Y, Takahashi, A, Momozawa, Y, Leveque, K, S, Nagayama, S, Mimori, K, Mori, M, Ishii, H, Inazawa, Yasuda, J, Tsuboi, A, Shimizu, A, Sasaki, M, Yamaji, T, Sawada, N, Iwasaki, M, Tsugane, S, Naito, M, Wakai, K, Koyama, T, Takezaki, T, Yuji, K, Murakami, Y, Nakamura, Y, Kubo, M, and Matsuda, K, GWAS identifies two novel colorectal cancer loci at 1 16q24.1 and 20q13.12, Carcinogenesis. 2018 May 3;39(5):652-660.

  • Sakai M, Takeuchi H, Yu Z, Kikuchi Y, Ono C, Takahashi Y, Ito F, Matsuoka H, Tanabe O, Yasuda J, Taki Y, Kawashima R, Tomita H. Polymorphisms in the microglial marker molecule CX3CR1 affect the blood volume of the human brain. Psychiatry Clin Neurosci. 2018 Feb 28. doi: 10.1111/pcn.12649.

  • Miyagi T, Takahashi K, Yamamoto K, Shiozaki K, Yamaguchi K. Biological and Pathological Roles of Ganglioside Sialidases. Prog Mol Biol Transl Sci, 156, 121-150 (2018)

  • Morita M, Sato T, Nomura M, Sakamoto Y, Inoue Y, Tanaka R, Ito S, Kurosawa K, Yamaguchi K, Sugiura Y, Takizaki H, Yamashita Y, Katakura R, Sato I, Kawai M, Okada Y, Watanabe H, Kondoh G, Matsumoto S, Kishimoto A, Obata M, Matsumoto M, Fukuhara T, Motohashi H, Suematsu M, Komatsu M, Nakayama KI, Watanabe T, Soga T, Shima H, Maemondo M, Tanuma N. PKM1 Confers Metabolic Advantages and Promotes Cell-Autonomous Tumor Cell Growth. Cancer Cell, 33, 355-367 (2018)

2017年

  • *Pan, X, Nariai, N, Fukuhara, N, Saito, S, Sato, Y, Katsuoka, F, Kojima, K, Kuroki, Y, Danjoh, I, Saito, R, Hasegawa, S, Okitsu, Y, Kondo, A, Onishi, Y, Nagami, F, Kiyomoto, H, Hozawa, A, Fuse, N, Nagasaki, M, Shimizu, R, Yasuda, J, Harigae, H and Yamamoto, M, Monitoring of minimal residual disease in early T-cell precursor acute lymphoblastic leukaemia by next-generation sequencing, Br J Haematol, 176, 2, 318-321, 2017

  • Hachiya, T, Furukawa, R, Shiwa, Y, Ohmomo, H, Ono, K, Katsuoka, F, Nagasaki, M, Yasuda, J, Fuse, N, Kinoshita, K, Yamamoto, M, Tanno, K, Satoh, M, Endo, R, Sasaki, M, Sakata, K, Kobayashi, S, Ogasawara, K, Hitomi, J, Sobue, K and Shimizu, A, Genome-wide identification of inter-individually variable DNA methylation sites improves the efficacy of epigenetic association studies, NPJ Genom Med, 2, 11, 2017

  • Hamanaka, T, Kimura, M, Sakurai, T, Ishida, N, Yasuda, J, Nagasaki, M, Nariai, N, Endo, A, Homma, K, Katsuoka, F, Matsubara, Y, Yamamoto, M and Fuse, N, A Histologic Categorization of Aqueous Outflow Routes in Familial Open-Angle Glaucoma and Associations With Mutations in the MYOC Gene in Japanese Patients, Invest Ophthalmol Vis Sci, 58, 5, 2818-2831, 2017

  • Nishioka, M, Bundo, M, Ueda, J, Katsuoka, F, Sato, Y, Kuroki, Y, Ishii, T, Ukai, W, Murayama, S, Hashimoto, E, Nagasaki, M, Yasuda, J, Kasai, K, Kato, T and Iwamoto, K, Identification of somatic mutations in postmortem human brains by whole genome sequencing and their implications for psychiatric disorders, Psychiatry Clin Neurosci, 2017

  • Shiga, Y, Nishiguchi, KM, Kawai, Y, Kojima, K, Sato, K, Fujita, K, Takahashi, M, Omodaka, K, Araie, M, Kashiwagi, K, Aihara, M, Iwata, T, Mabuchi, F, Takamoto, M, Ozaki, M, Kawase, K, Fuse, N, Yamamoto, M, Yasuda, J, Nagasaki, M, Nakazawa, T and Japan Glaucoma Society Omics, G, Genetic analysis of Japanese primary open-angle glaucoma patients and clinical characterization of risk alleles near CDKN2B-AS1, SIX6 and GAS7, PLoS One, 12, 12, e0186678, 2017

  • Takahashi K, Proshin S, Yamaguchi K, Yamashita Y, Katakura R, Yamamoto K, Shima H, Hosono M, Miyagi T. Sialidase NEU3 defines invasive potential of human glioblastoma cells by regulating calpain-mediated proteolysis of focal adhesion proteins. Biochim Biophys Acta, 1861, 2778-2788 (2017)

  • Seyrantepe V, Demir SA, Timur ZK, Von Gerichten J, Marsching C, Erdemli E, Oztas E, Takahashi K, Yamaguchi K, Ates N, Donmez Demir B, Dalkara T, Erich K, Hopf C, Sandhoff R, Miyagi T. Murine Sialidase Neu3 facilitates GM2 degradation and bypass in mouse model of Tay-Sachs disease. Exp Neurol, 299, 26-41 (2017)

  • Pan X, De Aragao CBP, Velasco-Martin JP, Priestman DA, Wu HY, Takahashi K, Yamaguchi K, Sturiale L, Garozzo D, Platt FM, Lamarche-Vane N, Morales CR, Miyagi T, Pshezhetsky AV. Neuraminidases 3 and 4 regulate neuronal function by catabolizing brain gangliosides. FASEB J, 31, 3467-3483 (2017)

  • Nasu, K., Yamaguchi K., Takanashi, T., Tamai, K., Sato, I., Ine, S., Sasaki, O., Satoh, K., Tanaka, N., Tanaka, Y., Fukushima, T., Harigae, H., and Sugamura, K. Crucial role of carbonic anhydrase IX in tumorigenicity of xenotransplanted adult T-cell leukemia-derived cells. Cancer Sci, 108, 435-443 (2017).

  • Shiroki, T, Yokoyama, M, Tanuma, N, Maejima, R, Tamai, K, Yamaguchi, K, Oikawa, T, Noguchi, T, Miura, K, Fujiya, T, Shima, H, Sato, I, Murata-Kamiya, N, Hatakeyama, M, Iijima, K, Shimosegawa, T, and Satoh, K Enhanced expression of the M2 isoform of pyruvate kinase is involved in gastric cancer development by regulating cancer-specific metabolism. Cancer Sci. 108, 931-940 (2017).

2016年

  • Koshiba, S, Motoike, I, Kojima, K, Hasegawa, T, Shirota, M, Saito, T, Saigusa, D, Danjoh, I, Katsuoka, F, Ogishima, S, Kawai, Y, Yamaguchi-Kabata, Y, Sakurai, M, Hirano, S, Nakata, J, Motohashi, H, Hozawa, A, Kuriyama, S, Minegishi, N, Nagasaki, M, Takai-Igarashi, T, Fuse, N, Kiyomoto, H, Sugawara, J, Suzuki, Y, Kure, S, Yaegashi, N, Tanabe, O, Kinoshita, K, Yasuda, J and Yamamoto, M, The structural origin of metabolic quantitative diversity, Sci Rep, 6, 31463, 2016

  • Kohda, M, Tokuzawa, Y, Kishita, Y, Nyuzuki, H, Moriyama, Y, Mizuno, Y, Hirata, T, Yatsuka, Y, Yamashita-Sugahara, Y, Nakachi, Y, Kato, H, Okuda, A, Tamaru, S, Borna, NN, Banshoya, K, Aigaki, T, Sato-Miyata, Y, Ohnuma, K, Suzuki, T, Nagao, A, Maehata, H, Matsuda, F, Higasa, K, Nagasaki, M, Yasuda, J, Yamamoto, M, Fushimi, T, Shimura, M, Kaiho-Ichimoto, K, Harashima, H, Yamazaki, T, Mori, M, Murayama, K, Ohtake, A and Okazaki, Y, A Comprehensive Genomic Analysis Reveals the Genetic Landscape of Mitochondrial Respiratory Chain Complex Deficiencies, PLoS Genet, 12, 1, e1005679, 2016

  • Kuriyama, S, Yaegashi, N, Nagami, F, Arai, T, Kawaguchi, Y, Osumi, N, Sakaida, M, Suzuki, Y, Nakayama, K, Hashizume, H, Tamiya, G, Kawame, H, Suzuki, K, Hozawa, A, Nakaya, N, Kikuya, M, Metoki, H, Tsuji, I, Fuse, N, Kiyomoto, H, Sugawara, J, Tsuboi, A, Egawa, S, Ito, K, Chida, K, Ishii, T, Tomita, H, Taki, Y, Minegishi, N, Ishii, N, Yasuda, J, Igarashi, K, Shimizu, R, Nagasaki, M, Koshiba, S, Kinoshita, K, Ogishima, S, Takai-Igarashi, T, Tominaga, T, Tanabe, O, Ohuchi, N, Shimosegawa, T, Kure, S, Tanaka, H, Ito, S, Hitomi, J, Tanno, K, Nakamura, M, Ogasawara, K, Kobayashi, S, Sakata, K, Satoh, M, Shimizu, A, Sasaki, M, Endo, R, Sobue, K, Tohoku Medical Megabank Project Study Group, T and Yamamoto, M, The Tohoku Medical Megabank Project: Design and Mission, J Epidemiol, 26, 9, 493-511, 2016

  • Saigusa, D, Okamura, Y, Motoike, IN, Katoh, Y, Kurosawa, Y, Saijyo, R, Koshiba, S, Yasuda, J, Motohashi, H, Sugawara, J, Tanabe, O, Kinoshita, K and Yamamoto, M, Establishment of Protocols for Global Metabolomics by LC-MS for Biomarker Discovery, PLoS One, 11, 8, e0160555, 2016Takahashi S, Satoh D, Hayashi M, Takahashi K, Yamaguchi K, Nakamura T, Koshino H. Total synthesis of the proposed structure for aromin and its structural revision. J Org Chem, 81, 11222-11234 (2016).

  • Yamaguchi K, Takanashi T, Nasu K, Tamai K, Mochizuki M, Satoh I, Ine S, Sasaki O, Satoh K, Tanaka N, Harigae H, Sugamura K. Xenotransplantation elicits salient tumorigenicity of adult T-cell leukemia-derived cells via aberrant AKT activation. Cancer Sci, 107, 638-643 (2016).

  • Mochizuki M, Tamai K, Imai T, Sugawara S, Ogama N, Nakamura M, Matsuura K, Yamaguchi K, Satoh K, Sato I, Motohashi H, Sugamura K, Tanaka N. CD271 regulates the proliferation and motility of hypopharyngeal cancer cells. Sci Rep, 6, 30707 (2016).

2015年

  • Nagasaki, M, Yasuda, J, Katsuoka, F, Nariai, N, Kojima, K, Kawai, Y, Yamaguchi-Kabata, Y, Yokozawa, J, Danjoh, I, Saito, S, Sato, Y, Mimori, T, Tsuda, K, Saito, R, Pan, X, Nishikawa, S, Ito, S, Kuroki, Y, Tanabe, O, Fuse, N, Kuriyama, S, Kiyomoto, H, Hozawa, A, Minegishi, N, Douglas Engel, J, Kinoshita, K, Kure, S, Yaegashi, N, To, MJRPP and Yamamoto, M, Rare variant discovery by deep whole-genome sequencing of 1,070 Japanese individuals, Nat Commun, 6, 8018, 2015

  • Kawai, Y, Mimori, T, Kojima, K, Nariai, N, Danjoh, I, Saito, R, Yasuda, J, Yamamoto, M and Nagasaki, M, Japonica array: improved genotype imputation by designing a population-specific SNP array with 1070 Japanese individuals, J Hum Genet, 60, 10, 581-7, 2015

  • Nariai, N, Kojima, K, Saito, S, Mimori, T, Sato, Y, Kawai, Y, Yamaguchi-Kabata, Y, Yasuda, J and Nagasaki, M, HLA-VBSeq: accurate HLA typing at full resolution from whole-genome sequencing data, BMC Genomics, 16 Suppl 2, S7, 2015

  • Yamaguchi-Kabata, Y, Nariai, N, Kawai, Y, Sato, Y, Kojima, K, Tateno, M, Katsuoka, F, Yasuda, J, Yamamoto, M and Nagasaki, M, iJGVD: an integrative Japanese genome variation database based on whole-genome sequencing, Hum Genome Var, 2, 15050, 2015

  • Abue M, Yokoyama M, Shibuya R, Tamai K, Yamaguchi K, Sato I, Tanaka N, Hamada S, Shimosegawa T, Sugamura K, Satoh K. Circulating miR-483-3p and miR-21 is highly expressed in plasma of pancreatic cancer. Int J Oncol, 46, 539-547 (2015).

  • Kuramitsu M, Okuma K, Yamagishi M, Yamochi T, Firouzi S, Momose H, Mizukami T, Takizawa K, Araki K, Sugamura K, Yamaguchi K, Watanabe T, Hamaguchi I. Identification of TL-Om1, an adult T-cell leukemia (ATL) cell line, as reference material for quantitative PCR for human T-lymphotropic virus 1. J Clin Microbiol, 53, 587-596 (2015).

  • Miyagi T, Takahashi K, Shiozaki K, Yamaguchi K, Hosono M. Plasma membrane-associated sialidase confers cancer initiation, promotion and progression. Adv Exp Med Biol, 842, 139-145 (2015).

  • Hata K, Tochigi T, Sato I, Kawamura S, Shiozaki K, Wada T, Takahashi K, Moriya S, Yamaguchi K, Hosono M, Miyagi T. Increased sialidase activity in serum of cancer patients: Identification of sialidase and inhibitor activities in human serum. Cancer Sci, 106, 383-389 (2015).

  • Shiozaki K, Takahashi K, Hosono M, Yamaguchi K, Hata K, Shiozaki M, Bassi R, Prinetti A, Sonnino S, Nitta K, Miyagi T. Phosphatidic acid-mediated activation and translocation to the cell surface of sialidase NEU3, promoting signaling for cell migration. FASEB J, 29, 2099-2111 (2015).

  • Takahashi K, Hosono M, Sato I, Hata K, Wada T, Yamaguchi K, Nitta K, Shima H, Miyagi T. Sialidase NEU3 contributes neoplastic potential on colon cancer cells as a key modulator of gangliosides by regulating Wnt signaling. Int J Cancer, 137, 1560-1573 (2015).

  • Yamamoto K, Takahashi K, Shiozaki K, Yamaguchi K, Moriya S, Hosono M, Shima H, Miyagi T. Potentiation of epidermal growth factor-mediated oncogenic transformation by sialidase NEU3 leading to Src activation. PLoS One, 10, e0120578 (2015).

2014年

  • Katsuoka, F, Yokozawa, J, Tsuda, K, Ito, S, Pan, X, Nagasaki, M, Yasuda, J and Yamamoto, M, An efficient quantitation method of next-generation sequencing libraries by using MiSeq sequencer, Anal Biochem, 466, 27-9, 2014

  • Motoike, IN, Matsumoto, M, Danjoh, I, Katsuoka, F, Kojima, K, Nariai, N, Sato, Y, Yamaguchi-Kabata, Y, Ito, S, Kudo, H, Nishijima, I, Nishikawa, S, Pan, X, Saito, R, Saito, S, Saito, T, Shirota, M, Tsuda, K, Yokozawa, J, Igarashi, K, Minegishi, N, Tanabe, O, Fuse, N, Nagasaki, M, Kinoshita, K, Yasuda, J and Yamamoto, M, Validation of multiple single nucleotide variation calls by additional exome analysis with a semiconductor sequencer to supplement data of whole-genome sequencing of a human population, BMC Genomics, 15, 673, 2014

  • Nagata T, Murata K, Murata R, Sun SL, Saito Y, Yamaga S, Tanaka N, Tamai K, Moriya K, Kasai N, Sugamura K, Ishii N. Hepatocyte growth factor regulated tyrosine kinase substrate in the peripheral development and function of B-cells. Biochem Biophys Res Commun, 443, 351-356 (2014).

  • Tamai K, Nakamura M, Mizuma M, Mochizuki M, Yokoyama M, Endo H, Yamaguchi K, Nakagawa T, Shiina M, Unno M, Muramoto K, Sato I, Satoh K, Sugamura K, Tanaka N. Suppressive expression of CD274 increases tumorigenesis and cancer stem cell phenotypes in cholangiocarcinoma. Cancer Sci, 105, 667-674 (2014).

  • Yamaki S, Ine S, Kawabe T, Okuyama Y, Suzuki N, Soroosh P, Mousavi SF, Nagashima H, Sun SL, So T, Sasaki T, Harigae H, Sugamura K, Kudo H, Wada M, Nio M, Ishii N. OX40 and IL-7 play synergistic roles in the homeostatic proliferation of effector memory CD4+ T cells. Eur J Immunol, 44, 3015-3025 (2014).

  • Kojima K, Amano Y, Yoshino K, Tanaka N, Sugamura K, Takeshita T. ESCRT-0 protein hepatocyte growth factor-regulated tyrosine kinase substrate (Hrs) is targeted to endosomes independently of signal-transducing adaptor molecule (STAM) and the complex formation with STAM promotes its endosomal dissociation. J Biol Chem, 289, 33296-33310 (2014).

2013年

  • Imai T, Tamai K, Oizumi S, Oyama K, Yamaguchi K, Sato I, Satoh K, Matsuura K, Saijo S, Sugamura K, Tanaka N. CD271 Defines a Stem Cell-Like Population in Hypopharyngeal Cancer. PLoS ONE, 8, e62002 (2013).

  • Horino S, Uchiyama T, So T, Nagashima H, Sun SL, Sato M, Asao A, Haji Y, Sasahara Y, Candotti F, Tsuchiya S, Kure S, Sugamura K, Ishii N. Gene therapy model of X-linked severe combined immunodeficiency using a modified foamy virus vector. PLoS One, 8, e71594 (2013).

  • Endo H, Shiroki T, Nakagawa T, Yokoyama M, Tamai K, Yamanami H, Fujiya T, Sato I, Yamaguchi K, Tanaka N, Iijima K, Shimosegawa T, Sugamura K, Satoh K. Enhanced expression of long non-coding RNA HOTAIR is associated with the development of gastric cancer. PLoS One, 8, e77070 (2013).

  • Shiozaki K, Takeshita K, Ikeda M, Ikeda A, Harasaki Y, Komatsu M, Yamada S, Yamaguchi K, Miyagi T. Molecular cloning and biochemical characterization of two novel Neu3 sialidases, neu3a and neu3b, from medaka (Oryzias latipes). Biochimie, 95, 280-289 (2013).

2012年

  • Koseki K, Wada T, Hosono M, Hata K, Yamaguchi K, Nitta K, Miyagi T. Human cytosolic sialidase NEU2-low general tissue expression but involvementin PC-3 prostate cancer cell survival. Biochem Biophys Res Commun, 428, 142-149 (2012).

  • Miyagi T, Takahashi K, Moriya S, Hata K, Yamamoto K, Wada T, Yamaguchi K, Shiozaki K. Altered expression of sialidases in human cancer. Adv Exp Med Biol, 749, 257-267 (2012).

  • Yamaguchi K, Shiozaki K, Moriya S, Koseki K, Wada T, Tateno H, Sato I, Asano M, Iwakura Y, Miyagi T. Reduced susceptibility to colitis-associated colon carcinogenesis in mice lacking plasma membrane-associated sialidase. PLoS One, 7, e41132 (2012).

  • Miyagi T, Yamaguchi K. Mammalian sialidases: Physiological and pathological roles in cellular functions. Glycobiology, 22, 880-896 (2012).

  • Takahashi K, Mitoma J, Hosono M, Shiozaki K, Sato C, Yamaguchi K, Kitajima K, Higashi H, Nitta K, Shima H, Miyagi T. Sialidase NEU4 hydrolyzes polysialic acids of neural cell adhesion molecules and negatively regulates neurite formation by hippocampal neurons. J Biol Chem, 287, 14816-14826 (2012).

  • Suzuki T, Yamaguchi K. Structure, Biosynthesis and Function Sialic Acid Glycoconjugates in Health and Disease, 2012, 188-208 Joe Tiralongo and Ivan Martinez-Duncker (Eds) 2012 Bentham Science Publishers CHAPTER 6 Mammalian Sialidases

  • Tamai K, Shiina M, Tanaka N, Nakano T, Yamamoto A, Kondo Y, Kakazu E, Inoue J, Fukushima K, Sano K, Ueno Y, Shimosegawa T, Sugamura K. Regulation of hepatitis C virus secretion by the Hrs-dependent exosomal pathway. Virology, 422, 377-385 (2012).

2011年

  • *Yokoo, H, Yasuda, J, Nakanishi, K, Chuma, M, Kamiyama, T, Todo, S, Hirohashi, S and Sakamoto, M, Clinicopathological significance of nuclear factor-kappaB activation in hepatocellular carcinoma, Hepatol Res, 41, 3, 240-9, 2011

  • Kawamura S, Sato I, Wada T, Yamaguchi K, Li Y, Li D, Zhao X, Ueno S, Aoki H, Tochigi T, Kuwahara M, Kitamura T, Takahashi K, Moriya S, Miyagi T. Plasma membrane-associated sialidase (NEU3) regulates progression of prostate cancer to androgen-independent growth through modulation of androgen receptor signaling. Cell Death Differ, 19, 170-179, (2011 Jun 17).

  • Suzuki S, Tamai K, Watanabe M, Kyuuma M, Ono M, Sugamura K, Tanaka N. AMSH is required to degrade ubiquitinated proteins in the central nervous system. Biochem Biophys Res Commun, 408, 582-588, (2011).

  • Amano Y, Yamashita Y, Kojima K, Yoshino K, Tanaka N, Sugamura K, Takeshita T. Hrs Recognizes a Hydrophobic Amino Acid Cluster in Cytokine Receptors during Ubiquitin-independent Endosomal Sorting. J Biol Chem, 286, 15458-72, (2011).

  • 山口壹範, 宮城妙子 シアリダーゼ、生物機能モデルと新しいリソースリサーチツール, pp340-345, エルアイシー, 2011

  • Shiozaki K, Yamaguchi K, Takahashi K, Moriya S, Miyagi T. Regulation of sialyl lewis antigen expression in colon cancer cells by sialidase NEU4. J Biol Chem, 286, 21052-21061, (2011).

2010年

  • Forrest, AR, Kanamori-Katayama, M, Tomaru, Y, Lassmann, T, Ninomiya, N, Takahashi, Y, de Hoon, MJ, Kubosaki, A, Kaiho, A, Suzuki, M, Yasuda, J, Kawai, J, Hayashizaki, Y, Hume, DA and Suzuki, H, Induction of microRNAs, mir-155, mir-222, mir-424 and mir-503, promotes monocytic differentiation through combinatorial regulation, Leukemia, 24, 2, 460-6, 2010

  • Sudo, K, Yasuda, J and Nakamura, Y, Gene expression profiles of cryopreserved CD34(+) human umbilical cord blood cells are related to their bone marrow reconstitution abilities in mouse xenografts, Biochem Biophys Res Commun, 397, 4, 697-705, 2010

  • Tamai K, Tanaka N, Nakano T, Kakazu E, Kondo Y, Inoue J, Shiina M, Fukushima K, Hoshino T, Sano K, Ueno Y, Shimosegawa T, Sugamura K. Exosome secretion of dendritic cells is regulated by Hrs, an ESCRT-0 protein. Biochem Biophys Res Commun, 27, 399(3), 384-90, (2010).

  • Yamaguchi K, Koseki K, Shiozaki M, Shimada Y, Wada T, Miyagi T. Regulation of plasma-membrane-associated sialidase NEU3 gene by Sp1/Sp3 transcription factors. Biochem J, 430, 107-117, (2010).

  • Katoh S, Maeda S, Fukuoka H, Wada T, Moriya S, Mori A, Yamaguchi K, Senda S, Miyagi T. A crucial role of sialidase neu1 in hyaluronan receptor function of CD44 in T helper type 2-mediated airway inflammation of murine acute asthmatic model. Clin Exp Immunol, 161, 233-241, (2010).

2009年

  • Shiozaki K, Yamaguchi K, Sato I, Miyagi T. Plasma membrane-associated sialidase (NEU3) promotes formation of colonic aberrant crypt foci in azoxymethane-treated transgenic mice. Cancer Sci, 100, 588-594, (2009).

  • Shiozaki K, Koseki K, Yamaguchi K, Shiozaki M, Narimatsu H, Miyagi T. Developmental change of sialidase neu4 expression in murine brain and its involvement in the regulation of neuronal cell differentiation. J Biol Chem, 284, 21157-21164, (2009).

  • Uemura T, Shiozaki K, Yamaguchi K, Miyazaki S, Satomi S, Kato K, Sakuraba H, Miyagi T. Contribution of sialidase NEU1 to suppression of metastasis of human colon cancer cells through desialylation of integrin beta4. Oncogene, 28, 1218-1229, (2009).

2008年

  • Kawaji, H, Nakamura, M, Takahashi, Y, Sandelin, A, Katayama, S, Fukuda, S, Daub, CO, Kai, C, Kawai, J, Yasuda, J, Carninci, P and Hayashizaki, Y, Hidden layers of human small RNAs, BMC Genomics, 9, 157, 2008

  • Yasuda, J and Hayashizaki, Y, The RNA continent, Adv Cancer Res, 99, 77-112, 2008 Carninci, P, Yasuda, J and Hayashizaki, Y, Multifaceted mammalian transcriptome, Curr Opin Cell Biol, 20, 3, 274-80, 2008

  • Tamai K, Toyoshima M, Tanaka N, Yamamoto N, Owada Y, Kiyonari H, Murata K, Ueno Y, Ono M, Shimosegawa T, Yaegashi N, Watanabe M, and Sugamura K. Loss of Hrs in the Central Nervous System Causes Accumulation of Ubiquitinated Proteins and Neurodegeneration. Am.J.Pathol, 173, 1806-17, (2008).

  • Tanaka Y, Tanaka, N, Saeki Y, Tanaka K, Murakami M, Hirano T, Ishii N, Sugamura K. c-Cbl-dependent Monoubiquitination and Lysosomal Degradation of gp130. Mol. Cell. Biol, 28, 4805-4818, (2008).

  • Tanaka N, Kyuuma M, Sugamura K. Endosomal sorting complex required for transport proteins in cancer pathogenesis, vesicular transport, and non-endosomal functions. Cancer Sci, 99, 1293-303, (2008).

  • Yamashita Y, Kojima K, Tsukahara T, Agawa H, Yamada K, Amano Y, Kurotori N, Tanaka N, Sugamura K, Takeshita T. Ubiquitin-independent binding of Hrs mediates endosomal sorting of the interleukin-2 receptor β-chain. J. Cell. Sci, 121, 1727-38, (2008).

  • Hata K, Koseki K, Yamaguchi K, Moriya S, Suzuki Y, Yingsakmongkon S, Hirai G, Sodeoka M, von Itzstein M, Miyagi T. Limited inhibitory effects of oseltamivir and zanamivir on human sialidases. Antimicrob Agents Chemother, 52, 3484-3491, (2008).

  • Miyagi T, Wada T, Yamaguchi K. Roles of plasma membrane-associated sialidase NEU3 in human cancers. Biochim Biophys Acta, 1780, 532-537, (2008).

  • Miyagi T, Wada T, Yamaguchi K, Hata K, Shiozaki K. Plasma membrane-associated sialidase as a crucial regulator of transmembrane signalling. J Biochem, 144, 279-285, (2008).

  • Miyagi T, Wada T, Yamaguchi K, Shiozaki K, Sato I, Kakugawa Y, Yamanami H, Fujiya T. Human sialidase as a cancer marker. Proteomics, 8, 3303-3311 (2008).

  • Yamaguchi K, Miyagi T. Function of NEU3 sialidase in membrane microdomains. Tanpakushitsu Kakusan Koso, 53(12 Suppl), 1570-1574, (2008, Sep).

2007年

  • Yasuda, J and Ichikawa, H, Mammalian Nemo-like kinase enhances beta-catenin-TCF transcription activity in human osteosarcoma and neuroblastoma cells, Proc Jpn Acad Ser B Phys Biol Sci, 83, 1, 16-25, 2007

  • Toyoshima M, Tanaka N, Aoki J, Tanaka Y, Murata K, Kyuuma M, Kobayashi H, Ishii N, Yaegashi N, Sugamura K. Inhibition of tumor growth and metastasis by depletion of vesicular sorting protein Hrs: its regulatory role on E-cadherin and beta-catenin. Cancer Res, 67, 5162-71, (2007).

  • Onoda T, Rahman M, Nara H, Araki A, Makabe K, Tsumoto K, Kumagai I, Kudo T, Ishii N, Tanaka N, Sugamura K, Hayasaka K, Asao H. Human CD4+ central and effector memory T cells produce IL-21: effect on cytokine-driven proliferation of CD4+ T cell subsets. Int Immunol, 10, 1191-9, (2007).

  • Tamai,K, Tanaka, N., Nara, A, Yamamoto,A Nakagawa, I., Yoshimori, T. Ueno, U, Shimosegawa, T, and Sugamura K. Role of Hrs in Maturation of Autophagosomes in Mammalian Cell. Biochem Biophys Res Commun, 360, 721-7, (2007).

  • Inoue Y, Tanaka N, Tanaka Y, Inoue S, Morita K, Min Z, Hattori T, Sugamura K. Clathrin-dependent Entry of SARS Coronavirus into Target Cells Expressing Cytoplasmic Tail-deleted ACE2. J Virol, 81, 8722-9, (2007).

  • Kyuuma M, Kikuchi K, Kojima K, Sugawara Y, Sato M, Mano N, Goto J, Takeshita T, Yamamoto A, Sugamura K, Tanaka N. AMSH, an ESCRT-III associated enzyme, deubiquitinates cargo on MVB/late endosomes. Cell Struct Funct, 31, 159-72, (2007).

  • Yamanami H, Shiozaki K, Wada T, Yamaguchi K, Uemura T, Kakugawa Y, Hujiya T, Miyagi T. Down-regulation of sialidase NEU4 may contribute to invasive properties of human colon cancers. Cancer Sci, 98, 299-307, (2007).

  • Miyagi T, Yamaguchi K. Sialic acids. In: Kamerling JP, Boons G-J, editors. Comprehensive Glycoscience : from chemistry to systems biology. Amsterdam; Boston: Elsevier; 2007. p. 297-323.

  • Yoshizumi S, Suzuki S, Hirai M, Hinokio Y, Yamada T, Yamada T, Tsunoda U, Aburatani H, Yamaguchi K, Miyagi T, Oka Y. Increased hepatic expression of ganglioside-specific sialidase, NEU3, improves insulin sensitivity and glucose tolerance in mice.
    Metabolism, 56, 420-429, (2007).

  • Wada T, Hata K, Yamaguchi K, Shiozaki K, Koseki K, Moriya S, Miyagi T. A crucial role of plasma membrane-associated sialidase in the survival of human cancer cells. Oncogene, 26, 2483-2490, (2007).

2006年

  • Nakashima A, Tanaka N, Tamai K, Kyuuma M, Ishikawa Y, Sato H, Yoshimori T, Saito S, Sugamura K. Survival of parvovirus B19-infected cells by cellular autophagy. Virology, 5, 349, 254-63, (2006).

  • Ishikawa Y, Tanaka N, Murakami K, Uchiyama T, Kumaki S, Tsuchiya S, Kugoh H, Oshimura M, Calos MP, Sugamura K. Phage phiC31 integrase-mediated genomic integration of the common cytokine receptor gamma chain in human T-cell lines. J Gene Med, 8, 646-653, (2006).

  • Uchiyama T, Kumaki S, Ishikawa Y, Onodera M, Sato M, Du W, Sasahara Y, Tanaka N, Sugamura K, Tsuchiya S. Application of HSVtk suicide gene to X-SCID gene therapy: ganciclovir treatment offsets gene corrected X-SCID B cells. Biochem Biophys Res Commun, 341(2), 391-8, (2006).

  • Yamaguchi K, Hata K, Wada T, Moriya S, Miyagi T. Epidermal growth factor-induced mobilization of a ganglioside-specific sialidase (NEU3) to membrane ruffles. Biochem Biophys Res Commun, 346, 484-490, (2006).

  • Kato K, Shiga K, Yamaguchi K, Hata K, Kobayashi T, Miyazaki K, Saijo S, Miyagi T. Plasma-membrane-associated sialidase (NEU3) differentially regulates integrin-mediated cell proliferation through laminin- and fibronectin-derived signalling. Biochem J, 394, 647-656, (2006).

  • Ueno S, Saito S, Wada T, Yamaguchi K, Satoh M, Arai Y, Miyagi T. Plasma membrane-associated sialidase is up-regulated in renal cell carcinoma and promotes interleukin-6-induced apoptosis suppression and cell motility. J Biol Chem, 281, 7756-7764, (2006).